Friedrich U, Therkelsen A J
Hum Genet. 1982;60(2):139-44. doi: 10.1007/BF00569700.
The lengths of the secondary constrictions of chromosomes 1, 9, and 16 vary with the degree of contraction of the chromosomes but these constrictions contract to a lesser degree than the euchromatic portions of the chromosomes. The regression coefficient for the regression of the length of the secondary constriction on the length of the euchromatic part of the chromosomes is shown to be larger for large constrictions. It is furthermore shown that there is a linear correlation between the regression coefficient and the size of the secondary constriction in question. This linear correlation makes it possible to correct the lengths of the secondary constrictions to the lengths expected when contraction is average. The correction method is used in a sample of 30 couples, and on the basis of this sample, the normal limits for the lengths of the secondary constrictions in chromosomes 1, 9, and 16 are defined.
1号、9号和16号染色体次缢痕的长度随染色体收缩程度而变化,但这些缢痕的收缩程度小于染色体的常染色质部分。结果表明,对于较大的缢痕,次缢痕长度与染色体常染色质部分长度的回归系数更大。此外还表明,回归系数与所讨论的次缢痕大小之间存在线性相关性。这种线性相关性使得可以将次缢痕的长度校正为收缩程度平均时预期的长度。在30对夫妇的样本中使用了这种校正方法,并基于该样本确定了1号、9号和16号染色体上次缢痕长度的正常范围。