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人类1号、9号、16号和Y染色体多态性的定量分析。I. 个体核型描述。

The quantitative analysis of polymorphism on human chromosomes 1, 9, 16, and Y. I. Description of individual karyotypes.

作者信息

Podugolnikova O A, Parfenova I V, Sushanlo H M, Prokofieva-Belgovskaja A A

出版信息

Hum Genet. 1979 Jul 18;49(3):243-50. doi: 10.1007/BF00569343.

Abstract

This study was made to establish a stable quantitative characteristic of C segments on chromosomes 1, 9, 16, and Y in an individual karyotype that was reproducible in successive experiments. The C segment of these chromosomes were measured in successive cultures of cells from three males and the C segments of chromosomes 1, 9, and 16 in cells from three pairs of female monozygotic twins were measured. The results show that the absolute lengths of C segments tend to vary considerably with the cell samples analyzed, while the relative length, i.e., the length of a single C segment as a percentage of the total length of all C segments of the chromosomes being studied, is more stable and can be used for individual characteristics.

摘要

本研究旨在建立个体核型中1号、9号、16号染色体及Y染色体C区段的稳定定量特征,该特征在连续实验中具有可重复性。对三名男性细胞的连续培养物中这些染色体的C区段进行了测量,并对三对女性同卵双胞胎细胞中1号、9号和16号染色体的C区段进行了测量。结果表明,C区段的绝对长度往往会因所分析的细胞样本而有很大差异,而相对长度,即单个C区段的长度占所研究染色体所有C区段总长度的百分比,则更为稳定,可用于个体特征分析。

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