Boesman-Finkelstein M, Finkelstein R A
Infect Immun. 1982 Apr;36(1):221-6. doi: 10.1128/iai.36.1.221-226.1982.
The avirulent, A-B+, streptomycin-resistant mutant designated Texas Star-SR, isolated from a virulent, hypertoxinogenic, colonizing strain of Vibrio cholerae (Ogawa serotype, El Tor biotype) and administered intragastrically or intraduodenally in adult rabbits, has been found to induce substantial immunity to subsequent challenge (in ligated intestinal loops) with virulent wild-type cholera vibrios (of both homologous and heterologous biotype and serotype). Significant resistance to challenge with one strain of human heat-labile enterotoxin (LT)-producing Escherichia coli was also demonstrated, but resistance against two other human LT-producing strains was either nil or marginal under these experimental conditions. Significant, but not striking, resistance against challenge with purified choleragen was obtained, whereas protection against a bolus challenge of purified porcine LT was not statistically significant.
从一株毒性强、产毒素多、具有定殖能力的霍乱弧菌（小川血清型，埃尔托生物型）中分离出的无毒A - B +链霉素抗性突变体，命名为德克萨斯之星 - SR，对成年兔进行胃内或十二指肠内给药后，已发现其能诱导对随后用毒性野生型霍乱弧菌（同源和异源生物型及血清型）进行攻击（在结扎肠袢中）产生显著免疫力。对一株产人热不稳定肠毒素（LT）的大肠杆菌攻击也表现出显著抗性，但在这些实验条件下，对另外两株产人LT的菌株的抗性要么为零，要么很微弱。对纯化霍乱原攻击获得了显著但不突出的抗性，而对纯化猪LT的一次大剂量攻击的保护作用在统计学上不显著。
