米诺环素与两性霉素B联合体外抗重要医学酵母的活性
Combined activity of minocycline and amphotericin B in vitro against medically important yeasts.
作者信息
Lew M A, Beckett K M, Levin M J
出版信息
Antimicrob Agents Chemother. 1978 Sep;14(3):465-9. doi: 10.1128/AAC.14.3.465.
Abstract
The capacity of minocycline to enhance the activity of amphotericin B against Candida albicans, Torulopsis glabrata, Cryptococcus neoformans, and non-albicans Candida was examined in vitro utilizing a time-killing curve technique. Synergism was apparent at 4 h with 5 of 5 strains of C. albicans, 8 of 8 strains of C. neoformans, and 1 of 12 strains of non-albicans Candida. Synergism was apparent at 24 h with the remaining 11 strains of non-albicans Candida and all 5 strains of T. glabrata. C. neoformans was the most susceptible of the yeasts to the minocycline-amphotericin B combination; seven strains showed a 3-log or greater reduction in colony count in 4 h and all strains showed this reduction in 24 h at amphotericin B concentrations of 0.4 mug/ml or less in the presence of minocycline.
摘要
利用时间杀菌曲线技术在体外检测了米诺环素增强两性霉素B对白色念珠菌、光滑念珠菌、新型隐球菌和非白色念珠菌活性的能力。在4小时时，5株白色念珠菌中的5株、8株新型隐球菌中的8株以及12株非白色念珠菌中的1株出现协同作用。在24小时时，其余11株非白色念珠菌和所有5株光滑念珠菌出现协同作用。新型隐球菌是酵母中对米诺环素-两性霉素B组合最敏感的；在米诺环素存在的情况下，当两性霉素B浓度为0.4μg/ml或更低时，7株新型隐球菌在4小时内菌落计数减少3个对数或更多，所有菌株在24小时内均出现这种减少。
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本文引用的文献
1
AMPHOTERICIN B TOXICITY; CHANGES IN RENAL MORPHOLOGY.两性霉素B毒性；肾脏形态学变化。
Ann Intern Med. 1964 Aug;61:349-54.
2
Bioassay for hamycin and amphotericin B in serum and other biological fluids.血清及其他生物体液中哈霉素和两性霉素B的生物测定法。
Appl Microbiol. 1969 Apr;17(4):497-503. doi: 10.1128/am.17.4.497-503.1969.
3
A pharmacologic guide to the clinical use of amphotericin B.两性霉素B临床应用的药理学指南
J Infect Dis. 1969 Oct;120(4):427-36. doi: 10.1093/infdis/120.4.427.
4
Studies on antibiotic synergism against enterococci. I. Bacteriologic studies.抗肠球菌抗生素协同作用的研究。I. 细菌学研究。
J Lab Clin Med. 1971 May;77(5):821-8.
5
Absorption and excretion of five tetracycline analogues in normal young men.正常青年男性体内五种四环素类似物的吸收与排泄
Am J Med Sci. 1968 May;255:296-312. doi: 10.1097/00000441-196805000-00005.
6
Inhibitors of protein synthesis by ribosomes of the 80-S type.80-S型核糖体蛋白质合成抑制剂。
Biochim Biophys Acta. 1971 Dec 16;254(2):316-30. doi: 10.1016/0005-2787(71)90840-9.
7
Potentiation of the antifungal effects of antibiotics by amphotericin B.两性霉素B增强抗生素的抗真菌作用。
Antimicrob Agents Chemother. 1972 Aug;2(2):61-5. doi: 10.1128/AAC.2.2.61.
8
Combined amphotericin B-tetracycline therapy for experimental coccidioidomycosis.两性霉素B联合四环素治疗实验性球孢子菌病
Antimicrob Agents Chemother. 1974 May;5(5):473-8. doi: 10.1128/AAC.5.5.473.
9
Stability of amphotericin B in fungal culture media.两性霉素B在真菌培养基中的稳定性。
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