Quigley H A, Addicks E M
Arch Ophthalmol. 1982 May;100(5):807-14. doi: 10.1001/archopht.1982.01030030811018.
We compared the clinical appearance of the retinal nerve fiber layer (NFL) and its histology in primate eyes. In 12 eyes with NFL lesions induced by orbital optic nerve trauma, clinical detection of NFL atrophy was possible after loss of 50% of the neural tissue in a given area. Some retinal areas with no visible NFL striations had remaining nerve fibers. The detectability of NFL atrophy was directly affected both by the pattern of nerve fiber loss as well as by the zone of the retina in which the loss occurred. While each nerve bundle gives rise to a single light striation nasal and temporal to the nerve head, this one-to-one correspondence is not true above and below the disc, where bundles are thicker and incompletely divided by glial septa.
我们比较了灵长类动物眼睛中视网膜神经纤维层（NFL）的临床表现及其组织学特征。在12只因眼眶视神经损伤导致NFL病变的眼睛中，当给定区域内50%的神经组织丧失后，临床上才有可能检测到NFL萎缩。一些没有可见NFL条纹的视网膜区域仍有残留的神经纤维。NFL萎缩的可检测性直接受到神经纤维丢失模式以及发生丢失的视网膜区域的影响。虽然每条神经束在神经乳头鼻侧和颞侧产生一条单一的浅色条纹，但在视盘上方和下方并非如此，那里的神经束更厚，并且没有被神经胶质隔膜完全分开。
