Pappas S C, Silverman M
Can Med Assoc J. 1982 Jun 15;126(12):1391-4.
Twelve cases of methanol poisoning are reviewed. The clinical presentation and biochemical features are described and the results of treatment with alkali, ethanol and dialysis reported. The outcome of methanol poisoning appears to be related more to the interval between the time of ingestion and the start of therapy and to the degree of acidosis than to the initial serum methanol level. Therefore, early and aggressive treatment with bicarbonate and ethanol and subsequent institution of hemodialysis are strongly recommended whenever methanol can be detected in the blood, especially when metabolic acidosis of the anion-gap type is present, when mental or visual disturbances are present, or when more than 30 ml of absolute methanol has been consumed.
回顾了12例甲醇中毒病例。描述了临床表现和生化特征，并报告了用碱、乙醇和透析治疗的结果。甲醇中毒的预后似乎更多地与摄入时间和治疗开始之间的间隔以及酸中毒程度有关，而不是与初始血清甲醇水平有关。因此，只要血液中能检测到甲醇，特别是存在阴离子间隙型代谢性酸中毒、存在精神或视觉障碍或摄入超过30毫升纯甲醇时，强烈建议早期积极使用碳酸氢盐和乙醇治疗，随后进行血液透析。
