异常血红蛋白中的血红素降解
Haem degradation in abnormal haemoglobins.
作者信息
Brown S B, Docherty J C
出版信息
Biochem J. 1978 Sep 1;173(3):985-7. doi: 10.1042/bj1730985.
Abstract
The coupled oxidation of certain abnormal haemoglobins leads to different bile-pigment isomer distributions from that of normal haemoglobin. The isomer pattern may be correlated with the structure of the abnormal haemoglobin in the neighbourhood of the haem pocket. This is support for haem degradation by an intramolecular reaction.
摘要
某些异常血红蛋白的偶联氧化导致胆汁色素异构体分布与正常血红蛋白不同。异构体模式可能与血红素口袋附近异常血红蛋白的结构相关。这支持了通过分子内反应进行血红素降解。
相似文献
1
Haem degradation in abnormal haemoglobins.异常血红蛋白中的血红素降解
Biochem J. 1978 Sep 1;173(3):985-7. doi: 10.1042/bj1730985.
2
Haem degradation in human haemoglobin in vitro. Separation of the contribution of the alpha- and beta-subunits.人血红蛋白在体外的血红素降解。α亚基和β亚基贡献的分离。
Biochem J. 1984 Sep 1;222(2):401-6. doi: 10.1042/bj2220401.
3
Changes in EPR spectra of M-type abnormal haemoglobins induced by deoxygenation and their implications for the haem-haem interaction.
Biochim Biophys Acta. 1967 Oct 23;147(2):407-9. doi: 10.1016/0005-2795(67)90426-6.
4
Degradation of haem compounds to bile pigments.血红素化合物降解为胆色素。
Nat New Biol. 1972 Sep 6;239(88):5-8. doi: 10.1038/newbio239005a0.
5
Isomeric incorporation of the haem into monomeric haemoglobins of Chironomus thummi thummi. 1. Isolation of chemically homogeneous haemoglobins. Evidence for the isomerism of the haem in the component III.血红素在摇蚊（Chironomus thummi thummi）单体血红蛋白中的异构掺入。1. 化学纯血红蛋白的分离。组分III中血红素异构现象的证据。
Eur J Biochem. 1980;108(1):79-87. doi: 10.1111/j.1432-1033.1980.tb04698.x.
6
Functional disorders of some haemoglobins mutated in the haem pocket.
Haematologia (Budap). 1974;8(1-4):87-95.
7
Bile pigment formation in vitro from haematin and other haem derivatives.血红素及其他血红素衍生物在体外形成胆色素
Biochem J. 1950 Aug;47(2):129-34. doi: 10.1042/bj0470129.
8
Studies on haem alpha-methenyl oxygenase. Isomeric structure of formylbiliverdin, a possible precursor of biliverdin.血红素α-次甲基加氧酶的研究。胆绿素的可能前体——甲酰胆绿素的异构结构。
Biochem J. 1967 Jul;104(1):20-2. doi: 10.1042/bj1040020.
9
Urinary excretion of isomers of biliverdin after destruction in vivo of haemoproteins and haemin.血蛋白和血红素在体内被破坏后胆绿素异构体的尿排泄情况。
Biochem J. 1985 Jul 15;229(2):477-83. doi: 10.1042/bj2290477.
10
Bile pigment synthesis in plants. Incorporation of haem into phycocyanobilin and phycobiliproteins in Cyanidium caldarium.植物中的胆汁色素合成。血红素掺入红球藻中的藻蓝胆素和藻胆蛋白。
Biochem J. 1981 Jan 15;194(1):137-47. doi: 10.1042/bj1940137.
引用本文的文献
1
Haem disorder in reconstituted human haemoglobin.重组人血红蛋白中的血液疾病。
Biochem J. 1982 Dec 1;207(3):583-7. doi: 10.1042/bj2070583.
2
Formation of bile pigments by coupled oxidation of cobalt-substituted haemoglobin and myoglobin.钴取代的血红蛋白和肌红蛋白通过偶联氧化形成胆色素。
Biochem J. 1984 Oct 1;223(1):205-9. doi: 10.1042/bj2230205.
3
Haem degradation in human haemoglobin in vitro. Separation of the contribution of the alpha- and beta-subunits.人血红蛋白在体外的血红素降解。α亚基和β亚基贡献的分离。
Biochem J. 1984 Sep 1;222(2):401-6. doi: 10.1042/bj2220401.
4
Theoretical prediction and experimental measurement of the bile-pigment isomer pattern obtained from degradation of catalase haem.从过氧化氢酶血红素降解获得的胆汁色素异构体模式的理论预测和实验测量
Biochem J. 1986 May 15;236(1):303-6. doi: 10.1042/bj2360303.
本文引用的文献
1
HAEM catabolism and coupled oxidation of haemproteins.血红素分解代谢与血红素蛋白的偶联氧化
FEBS Lett. 1969 Nov 29;5(4):295-298. doi: 10.1016/0014-5793(69)80372-8.
2
Molecular pathology of human haemoglobin.人类血红蛋白的分子病理学
Nature. 1968 Aug 31;219(5157):902-9. doi: 10.1038/219902a0.
3
Structural investigations of modified haemoglobins by nuclear magnetic resonance spectroscopy.利用核磁共振光谱法对修饰血红蛋白进行结构研究。
J Mol Biol. 1972 Feb 14;63(3):477-82. doi: 10.1016/0022-2836(72)90442-1.
4
Haemoglobin catabolism: the role of ferrihaems in studies of the degradation pathway.血红蛋白分解代谢：高铁血红素在降解途径研究中的作用。
Biochem J. 1974 Jan;137(1):135-7. doi: 10.1042/bj1370135.
5
The meso-reactivity of porphyrins and related compounds. VI. Oxidative cleavage of the haem system. The four isomeric biliverdins of the IX series.卟啉及相关化合物的中位反应活性。VI. 血红素系统的氧化裂解。IX系列的四种异构胆绿素。
J Chem Soc Perkin 1. 1973;9:881-8. doi: 10.1039/p19730000881.
6
The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.微粒体血红素加氧酶将血红素酶促转化为胆红素。
Proc Natl Acad Sci U S A. 1968 Oct;61(2):748-55. doi: 10.1073/pnas.61.2.748.
7
The electronic structure of the haem iron in haemoglobin Zurich beta 63his-arg.
J Mol Biol. 1972 Oct 14;70(3):665-74. doi: 10.1016/0022-2836(72)90565-7.
8
The enzymatic formation of bilirubin.胆红素的酶促形成。
Ann N Y Acad Sci. 1975 Apr 15;244:533-52. doi: 10.1111/j.1749-6632.1975.tb41553.x.
9
Stereospecific haem cleavage. A model for the formation of bile-pigment isomers in vivo and in vitro.立体特异性血红素裂解。体内和体外胆汁色素异构体形成的模型。
Biochem J. 1976 Oct 1;159(1):23-7. doi: 10.1042/bj1590023.
10
Structure and mechanism of haemoglobin.血红蛋白的结构与机制。
Br Med Bull. 1976 Sep;32(3):195-208. doi: 10.1093/oxfordjournals.bmb.a071363.
Zotero 插件