Thomas W E
Dig Dis Sci. 1982 Jul;27(7):609-14. doi: 10.1007/BF01297217.
The effects of truncal vagotomy on the functional and morphological changes produced by duodenogastric reflux have been studied in the dog. Duodenogastric reflux caused progressive damage to gastric mucosa, hypersecretion of acid to pentagastrin, and a hypergastrinemic response to a standard meal. Truncal vagotomy barely altered the mucosal changes produced by reflux, but it did prevent antral gland hyperplasia and reduced the acid and gastrin secretory responses. These findings are clinically reassuring in that vagotomy effectively prevented the hypersecretory state produced by duodenogastric reflux.
已在犬身上研究了迷走神经干切断术对十二指肠-胃反流所产生的功能和形态学变化的影响。十二指肠-胃反流导致胃黏膜进行性损伤、对五肽胃泌素的胃酸分泌过多，以及对标准餐的高胃泌素血症反应。迷走神经干切断术几乎未改变反流所引起的黏膜变化，但确实可防止胃窦腺增生，并降低胃酸和胃泌素分泌反应。这些发现从临床上看令人安心，因为迷走神经切断术有效地预防了十二指肠-胃反流所产生的分泌过多状态。
