Thomas W E
Gut. 1980 May;21(5):413-7. doi: 10.1136/gut.21.5.413.
The effects of duodenal reflux on gastric secretion have been examined in dogs. Acid secretion during pentagastrin stimulation increased by 68% in animals with chronic diversion of duodenal contents into the stomach. This increased acid secretion did not occur when bile alone was diverted into the stomach and could be abolished by vagotomy. The hypersecretion observed with pentagastrin did not occur when histamine was the stimulus, which suggests that it was not due solely to a trophic effect on parietal cells.
在狗身上研究了十二指肠反流对胃液分泌的影响。在将十二指肠内容物长期转流至胃内的动物中，五肽胃泌素刺激期间的胃酸分泌增加了68%。当仅将胆汁转流至胃内时，这种胃酸分泌增加并未出现，且可通过迷走神经切断术消除。当以组胺作为刺激物时，五肽胃泌素刺激时观察到的胃酸分泌过多并未出现，这表明其并非仅仅是由于对壁细胞的营养作用所致。
