生长抑素对伴有和不伴有十二指肠-胃反流犬胃酸分泌及血清胃泌素的抑制作用
Inhibitory effect of somatostatin on gastric acid secretion and serum gastrin in dogs with and without duodenogastric reflux.
作者信息
Thomas W E
出版信息
Gut. 1980 Nov;21(11):996-1001. doi: 10.1136/gut.21.11.996.
Abstract
The hypersecretion of gastric acid in response to pentagastrin, caused by duodenal reflux, was tested in dogs. An infusion of 0.25 micrograms/kg/h was found to restore the raised responses seen in the reflux dogs to control levels. Somatostatin was a strong inhibitor of pentagastrin-stimulated acid secretion and of gastrin release, but it was a weak inhibitor of histamine. These studies suggest that somatostatin may have played a part in acid homeostasis.
摘要
在狗身上测试了十二指肠反流引起的对五肽胃泌素的胃酸分泌过多情况。发现以0.25微克/千克/小时的速度输注可将反流狗中出现的升高反应恢复到对照水平。生长抑素是五肽胃泌素刺激的胃酸分泌和胃泌素释放的强抑制剂，但它是组胺的弱抑制剂。这些研究表明生长抑素可能在胃酸稳态中发挥了作用。
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