Araake M
Microbiol Immunol. 1982;26(1):1-14. doi: 10.1111/j.1348-0421.1982.tb00148.x.
The cilia-stopping effect of mycoplasmas of human and various animal origin in mouse and chicken tracheal organ cultures was studied. From the results in mouse tracheal organ cultures, the mycoplasma strains tested were divided into three groups: Mycoplasma pulmonis m53, M pulmonis JB, M. pulmonis OK, M. mycoides subsp. Mycoides PGl and M. Gallisepticum S6 showed a strong cilia-stopping effect; M. pulmonis PG22, M. mycoides subsp. capri PG3, M. meleagridis 19729, M. neurolyticum Type A and M. arthritidis PG6 showed a mild effect; and M. pneumoniae FH, M. salivarium Hup, M. hominis type 1-C and M. orale N-C human origin and Acholeplasma laidlawii PG8 showed a weak effect. On the other hand, in chicken tracheal organ cultures, only M. gallisepticum S6 showed a strong effect, M. meleagridis 19729 was affected to a lesser degree, and the other mycoplasma strains showed a weak or no effect. The results indicate that some murine and poultry mycoplasmas showed a cilia-stopping tendency in mouse and chicken tracheal organ cultures, respectively, while human mycoplasmas showed weak or little effect in both organ cultures. In mouse tracheal organ cultures, M. pulmonis m53 treated with heat, trypsin or formaldehyde, and the sterile filtrate of an m53 broth culture showed no cilia-stopping effect. The relationship of the pathogenicity of mycoplasmas for their natural hosts to that for cultured respiratory cells is discussed.
研究了源自人类和各种动物的支原体在小鼠和鸡气管器官培养物中的纤毛停止效应。根据小鼠气管器官培养物的结果，所测试的支原体菌株分为三组：肺支原体m53、肺支原体JB、肺支原体OK、丝状支原体丝状亚种PGl和鸡毒支原体S6表现出强烈的纤毛停止效应；肺支原体PG22、丝状支原体山羊亚种PG3、火鸡支原体19729、溶神经支原体A型和关节炎支原体PG6表现出轻微效应；肺炎支原体FH、唾液支原体Hup、人型支原体1-C、口腔支原体N-C（源自人类）和莱氏无胆甾原体PG8表现出微弱效应。另一方面，在鸡气管器官培养物中，只有鸡毒支原体S6表现出强烈效应，火鸡支原体19729受到的影响较小，而其他支原体菌株表现出微弱或无效应。结果表明，一些鼠源和禽源支原体分别在小鼠和鸡气管器官培养物中表现出纤毛停止倾向，而人源支原体在两种器官培养物中均表现出微弱或几乎没有效应。在小鼠气管器官培养物中，经加热、胰蛋白酶或甲醛处理的肺支原体m53以及m53肉汤培养物的无菌滤液均未表现出纤毛停止效应。文中还讨论了支原体对其天然宿主的致病性与对培养的呼吸道细胞的致病性之间的关系。
