Batt R M, Morgan J O
Res Vet Sci. 1982 Jan;32(1):17-22.
Serum folate and vitamin B12 concentrations have been measured in 53 dogs presented for an investigation of malabsorption. Abnormal concentrations have permitted the differentiation of animals with small intestinal disease into three main groups, each with distinct biochemical abnormalities in the jejunal mucosa. The first group had reduced folate and vitamin B12 concentrations. Jejunal biopsies revealed marked villous atrophy and generalised biochemical abnormalities in the brush borders, lysosomes and endoplasmic reticulum. The second group had reduced folate but normal vitamin B12 concentrations and although histological changes were minimal there were specific biochemical changes confined to the brush borders. In the third group, increased folate and reduced vitamin B12 concentrations suggested a bacterial overgrowth in the proximal small intestine. Minor histological changes were accompanied by marked biochemical changes in brush borders and lysosomes. A group of animals with severe exocrine pancreatic insufficiency had increased mean folate but reduced mean vitamin B12 concentrations. These changes are consistent with bacterial overgrowth, but could be due to defective degradation of a B12-binding protein.
对53只因吸收不良前来检查的犬只测量了血清叶酸和维生素B12浓度。异常浓度使得患有小肠疾病的动物可分为三大组，每组在空肠黏膜中都有独特的生化异常。第一组叶酸和维生素B12浓度降低。空肠活检显示明显的绒毛萎缩以及刷状缘、溶酶体和内质网普遍存在生化异常。第二组叶酸浓度降低但维生素B12浓度正常，尽管组织学变化轻微，但存在局限于刷状缘的特定生化变化。在第三组中，叶酸浓度升高和维生素B12浓度降低表明近端小肠细菌过度生长。轻微的组织学变化伴随着刷状缘和溶酶体明显的生化变化。一组患有严重外分泌性胰腺功能不全的动物平均叶酸浓度升高但平均维生素B12浓度降低。这些变化与细菌过度生长一致，但可能是由于维生素B12结合蛋白降解缺陷所致。
