Tyrer P
Br Med J. 1978 Oct 7;2(6143):1008-10. doi: 10.1136/bmj.2.6143.1008.
The prescribing of psychotropic drugs by general practitioners was assessed by analysing the drug treatment of all patients referred from general practice to a psychiatric outpatient clinic over four years. Of the 287 patients, 220 were taking one or more of 56 different psychotropic drugs at referral, diazepam being the most common. Benzodiazepines and barbiturates had been taken for significantly longer than other drugs, and, of a total of 342 drugs, 61 had been prescribed regularly for over a year. Half of the drugs were considered to be incorrectly prescribed on pharmacological grounds, the main errors being unnecessarily prolonged regular treatment, incorrect dosage (particularly common with antidepressants), and polypharmacy with drugs of similar pharmacological action. A basic grounding in the pharmacology of psychotropic drugs might help practitioners to avoid prescribing errors of this kind.
通过分析四年来从全科医疗转诊至精神科门诊的所有患者的药物治疗情况,对全科医生开具精神类药物的情况进行了评估。在这287名患者中,有220名在转诊时正在服用56种不同精神类药物中的一种或多种,其中地西泮最为常见。苯二氮䓬类药物和巴比妥类药物的服用时间明显长于其他药物,在总共342种药物中,有61种被定期开具超过一年。从药理学角度来看,一半的药物被认为开具不当,主要错误包括不必要地延长常规治疗、剂量错误(抗抑郁药中尤为常见)以及使用药理作用相似的药物进行联合用药。对精神类药物药理学有基本的了解可能有助于从业者避免此类处方错误。