胰高血糖素通过降低离体肝细胞中3-磷酸甘油的含量来抑制三酰甘油的合成。
Glucagon inhibits triacylglycerol synthesis in isolated hepatocytes by lowering their glycerol 3-phosphate content.
作者信息
Declercq P E, Debeer L J, Mannaerts G P
出版信息
Biochem J. 1982 Mar 15;202(3):803-6. doi: 10.1042/bj2020803.
Abstract
Triacylglycerol synthesis by glycogen-depleted hepatocytes from fed rats that have low glycerol 3-phosphate contents was stimulated by the addition of glycerol 3-phosphate precursors. Glucagon decreased triacylglycerol synthesis only when it also lowered glycerol 3-phosphate content. The hyperbolic-like relationship between glycerol 3-phosphate content and rates of triacylglycerol synthesis was identical in the absence or presence of glucagon, indicating that the glucagon effect on triacylglycerol synthesis was not mediated through changes in enzyme activities of the esterification pathway but through changes in cellular glycerol 3-phosphate content.
摘要
来自喂食后甘油 3 - 磷酸含量较低的大鼠的糖原耗尽的肝细胞，通过添加甘油 3 - 磷酸前体可刺激三酰甘油的合成。只有当胰高血糖素降低甘油 3 - 磷酸含量时，它才会降低三酰甘油的合成。在有无胰高血糖素的情况下，甘油 3 - 磷酸含量与三酰甘油合成速率之间的双曲线样关系是相同的，这表明胰高血糖素对三酰甘油合成的影响不是通过酯化途径的酶活性变化介导的，而是通过细胞内甘油 3 - 磷酸含量的变化介导的。
相似文献
1
Glucagon inhibits triacylglycerol synthesis in isolated hepatocytes by lowering their glycerol 3-phosphate content.胰高血糖素通过降低离体肝细胞中3-磷酸甘油的含量来抑制三酰甘油的合成。
Biochem J. 1982 Mar 15;202(3):803-6. doi: 10.1042/bj2020803.
2
Role of glycerol 3-phosphate and glycerophosphate acyltransferase in the nutritional control of hepatic triacylglycerol synthesis.3-磷酸甘油和甘油磷酸酰基转移酶在肝脏三酰甘油合成营养调控中的作用
Biochem J. 1982 Apr 15;204(1):247-56. doi: 10.1042/bj2040247.
3
Glycerol-3-phosphate content and triacylglycerol synthesis in isolated hepatocytes from fed and starved rats.喂食和饥饿大鼠分离肝细胞中甘油-3-磷酸含量及三酰甘油合成
FEBS Lett. 1981 Feb 9;124(1):31-4. doi: 10.1016/0014-5793(81)80047-6.
4
Stimulation by ethanol of triglyceride synthesis in fasted rat hepatocytes is dependent on the increase of glycerol 3-phosphate levels.
Biochem Int. 1987 Mar;14(3):475-82.
5
Regulation of palmitate esterification/oxidation by glucagon in isolated hepatocytes: the role of alpha-glycerophosphate concentration.胰高血糖素对分离肝细胞中棕榈酸酯化/氧化的调节：α-甘油磷酸浓度的作用。
Biochim Biophys Acta. 1980 Dec 5;620(3):364-71. doi: 10.1016/0005-2760(80)90128-9.
6
Effects of hydration state on the synthesis and secretion of triacylglycerol by isolated rat hepatocytes. Implications for the actions of insulin and glucagon on hepatic secretion.水合状态对分离的大鼠肝细胞合成和分泌三酰甘油的影响。对胰岛素和胰高血糖素肝脏分泌作用的启示。
Biochem J. 1995 Nov 15;312 ( Pt 1)(Pt 1):57-62. doi: 10.1042/bj3120057.
7
The specificity of triacylglycerol synthesis for medium-chain fatty acids in rat and human adipose preparations.大鼠和人类脂肪制剂中三酰甘油合成对中链脂肪酸的特异性。
Biochim Biophys Acta. 1985 Aug 22;836(1):63-6. doi: 10.1016/0005-2760(85)90220-6.
8
Effects of vasopressin, glucagon and dibutyryl cyclic AMP on the activities of enzymes of fatty acid esterification in rat hepatocytes.血管加压素、胰高血糖素和二丁酰环磷酸腺苷对大鼠肝细胞脂肪酸酯化酶活性的影响。
FEBS Lett. 1980 Oct 6;119(2):312-6. doi: 10.1016/0014-5793(80)80279-1.
9
Regulation of net triacylglycerol synthesis by metabolic substrates in isolated rat liver cells.离体大鼠肝细胞中代谢底物对三酰甘油净合成的调节作用
Hoppe Seylers Z Physiol Chem. 1980 Jul;361(7):985-93. doi: 10.1515/bchm2.1980.361.2.985.
10
Accumulation of triacylglycerol in cultured rat hepatocytes is increased by ethanol and by insulin and dexamethasone.乙醇、胰岛素和地塞米松可增加培养的大鼠肝细胞中三酰甘油的积累。
Biochem J. 1983 Jun 15;212(3):617-23. doi: 10.1042/bj2120617.
引用本文的文献
1
Regulation of hepatic triacylglycerol synthesis and secretion.肝脏三酰甘油合成与分泌的调节
Vet Res Commun. 1984 Aug;8(3):157-71. doi: 10.1007/BF02214708.
2
Fatty acids reverse the cyclic AMP inhibition of triacylglycerol and phosphatidylcholine synthesis in rat hepatocytes.脂肪酸可逆转环磷酸腺苷对大鼠肝细胞中三酰甘油和磷脂酰胆碱合成的抑制作用。
Biochem J. 1983 Oct 15;216(1):129-36. doi: 10.1042/bj2160129.
3
What is the function of phospholipid N-methylation?磷脂N-甲基化的功能是什么？
Biochem J. 1983 Jul 1;213(1):1-10. doi: 10.1042/bj2130001.
4
Regulation of ketogenesis, gluconeogenesis and the mitochondrial redox state by dexamethasone in hepatocyte monolayer cultures.地塞米松对单层培养肝细胞中酮体生成、糖异生及线粒体氧化还原状态的调节作用
Biochem J. 1986 Nov 1;239(3):593-601. doi: 10.1042/bj2390593.
5
Biphasic effects of glucagon and cyclic AMP on the synthesis and secretion of lipids by rat hepatocytes.胰高血糖素和环磷酸腺苷对大鼠肝细胞脂质合成与分泌的双相作用。
Biochem J. 1991 Nov 1;279 ( Pt 3)(Pt 3):705-9. doi: 10.1042/bj2790705.
本文引用的文献
1
Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats.血管升压素与胰高血糖素对喂食大鼠分离肝细胞中酮体生成和油酸代谢的相互作用。
Biochem J. 1980 Feb 15;186(2):621-4. doi: 10.1042/bj1860621.
2
Regulation of palmitate esterification/oxidation by glucagon in isolated hepatocytes: the role of alpha-glycerophosphate concentration.胰高血糖素对分离肝细胞中棕榈酸酯化/氧化的调节：α-甘油磷酸浓度的作用。
Biochim Biophys Acta. 1980 Dec 5;620(3):364-71. doi: 10.1016/0005-2760(80)90128-9.
3
Glycerol-3-phosphate content and triacylglycerol synthesis in isolated hepatocytes from fed and starved rats.喂食和饥饿大鼠分离肝细胞中甘油-3-磷酸含量及三酰甘油合成
FEBS Lett. 1981 Feb 9;124(1):31-4. doi: 10.1016/0014-5793(81)80047-6.
4
Regulation of triacylglycerol synthesis in the liver: a decrease in diacylglycerol acyltransferase activity after treatment of isolated rat hepatocytes with glucagon.肝脏中三酰甘油合成的调节：用胰高血糖素处理分离的大鼠肝细胞后二酰甘油酰基转移酶活性降低。
Biochim Biophys Acta. 1981 Apr 23;664(1):74-81. doi: 10.1016/0005-2760(81)90029-1.
5
Effects of vasopressin, glucagon and dibutyryl cyclic AMP on the activities of enzymes of fatty acid esterification in rat hepatocytes.血管加压素、胰高血糖素和二丁酰环磷酸腺苷对大鼠肝细胞脂肪酸酯化酶活性的影响。
FEBS Lett. 1980 Oct 6;119(2):312-6. doi: 10.1016/0014-5793(80)80279-1.
6
Enzymes of glycerolipid synthesis in eukaryotes.真核生物中甘油脂质合成的酶。
Annu Rev Biochem. 1980;49:459-87. doi: 10.1146/annurev.bi.49.070180.002331.
7
Regulation of hepatic fatty acid oxidation and ketone body production.肝脏脂肪酸氧化及酮体生成的调节。
Annu Rev Biochem. 1980;49:395-420. doi: 10.1146/annurev.bi.49.070180.002143.
8
Acute effects of insulin on fatty acid metabolism in isolated rat hepatocytes.胰岛素对分离的大鼠肝细胞脂肪酸代谢的急性影响。
Horm Metab Res. 1980 Sep;12(9):425-30. doi: 10.1055/s-2007-999166.
9
Zotero 插件