Traub R D
Neuroscience. 1982 May;7(5):1233-42. doi: 10.1016/0306-4522(82)91130-7.
Dendritic recordings from hippocampal pyramidal cells suggest that bursts of action potentials--riding on a depolarizing wave and terminating in a slow calcium-mediated spike--can be generated locally in the dendrites, as well as at the soma. These data necessitated revision of our earlier model in which bursts at the soma are generated by interaction of two spatially separated conductance systems--a fast-spike sodium mechanism at the soma and a slow-spike calcium mechanism on the apical dendrite. We have introduced into a model of the CA3 hippocampal neuron two experimentally testable concepts: voltage-dependent inactivation of Ik and partial inactivation of ICa by Ca2+ ion. With these mechanisms, the model accurately reproduces bursts generated in either soma or in the apical dendrites by sets of conductances all located in the same respective membrane region. The model is also capable of bursting repetitively in response to continuous stimulation.
对海马锥体细胞的树突记录表明，动作电位爆发——叠加在去极化波上并终止于缓慢的钙介导尖峰——可在树突局部以及胞体产生。这些数据使得我们有必要修正我们早期的模型，在该模型中，胞体处的爆发是由两个空间分离的电导系统相互作用产生的——胞体处的快速尖峰钠机制和顶端树突上的缓慢尖峰钙机制。我们在CA3海马神经元模型中引入了两个可通过实验检验的概念：Ik的电压依赖性失活和Ca2+离子对ICa的部分失活。有了这些机制，该模型能准确再现由位于同一相应膜区域的电导集在胞体或顶端树突中产生的爆发。该模型还能够响应持续刺激而重复爆发。
