小鼠对急性和持续性麻疹感染的易感性。
Susceptibility of mice to acute and persistent measles infection.
作者信息
Neighbour P A, Rager-Zisman B, Bloom B R
出版信息
Infect Immun. 1978 Sep;21(3):764-70. doi: 10.1128/iai.21.3.764-770.1978.
Abstract
Intracerebral inoculation of neonatal mice with the Edmonston strain of measles virus produced an acute, lethal encephalitis and thymic dysplasia in susceptible mice. There was an age-related development of resistance to infection. This resistance was strain-dependent and appeared to be associated with the extent of virus growth in the brain. Studies on the genetic basis for susceptibility, using hybrid and backcross mice, revealed that the principal determinant of host resistance to acute infection was a dominant gene or genes which segregated independently of the H-2 complex. A small number of survivors of the acute infection showed persistence of measles virus antigens in the cerebellum and spleen for up to 2 months after inoculation. However, the low frequency of this persistence indicated that, at this time, intracerebral inoculation of neonatal mice with the Edmonston strain of measles virus constitutes a difficult model for the study of persistant measles infection.
摘要
用麻疹病毒埃德蒙斯顿株对新生小鼠进行脑内接种，在易感小鼠中引发了急性致死性脑炎和胸腺发育不良。对感染的抵抗力存在与年龄相关的发展过程。这种抵抗力具有毒株依赖性，并且似乎与病毒在脑中的生长程度有关。利用杂交和回交小鼠对易感性的遗传基础进行的研究表明，宿主对急性感染抵抗力的主要决定因素是一个或多个独立于H-2复合体分离的显性基因。急性感染的少数幸存者在接种后长达2个月的时间里，小脑和脾脏中持续存在麻疹病毒抗原。然而，这种持续性的低频率表明，此时用麻疹病毒埃德蒙斯顿株对新生小鼠进行脑内接种，对于研究麻疹病毒持续感染而言是一个困难的模型。
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