Tanner A R, Scott-Morgan L, Mardell R, Lloyd R S
Acta Endocrinol (Copenh). 1982 May;100(1):31-5. doi: 10.1530/acta.0.1000031.
The presence of thyroid microsomal and/or thyroglobulin antibodies has been recorded over a 2 year period of 15 000 consecutive autoimmune profile request. Where there had been no initial clinical suspicion of thyroid diseases, 332 requests showed positive thyroid antibodies, and of these 63 (19%) had abnormal in vitro thyroid function tests (TFT). No differences were observed between the abnormal and normal groups with respect to the presence of different autoantibodies or to the age and sex distributions. Of these subjects with clinically unsuspected hypothyroidism but with abnormal TFTs, 29% were commenced on thyroxine therapy and experienced a symptomatic improvement, 25% remain well on no therapy and 9% continue on no treatment but with symptoms possibly attributable to hypothyroidism. 3% became clinically hypothyroid during a follow-up period of 2 years. 5% died of unrelated causes and there was inadequate follow-up information on the remainder. This study provides further confirmation that when thyroid antibodies, and in particular thyroid microsomal antibody, are found unexpectedly, a significant proportion of patients will have biochemical evidence of hypothyroidism and may benefit from appropriate treatment.
在连续15000例自身免疫谱检测的2年期间，记录到甲状腺微粒体抗体和/或甲状腺球蛋白抗体的存在情况。在最初没有临床怀疑甲状腺疾病的情况下，332例检测显示甲状腺抗体呈阳性，其中63例（19%）体外甲状腺功能试验（TFT）异常。在不同自身抗体的存在情况以及年龄和性别分布方面，异常组和正常组之间未观察到差异。在这些临床上未被怀疑患有甲状腺功能减退但TFT异常的受试者中，29%开始接受甲状腺素治疗并症状改善，25%未接受治疗但情况良好，9%未接受治疗但可能有甲状腺功能减退相关症状。在2年的随访期内，3%发展为临床甲状腺功能减退。5%死于无关原因，其余患者的随访信息不足。这项研究进一步证实，当意外发现甲状腺抗体，尤其是甲状腺微粒体抗体时，很大一部分患者会有甲状腺功能减退的生化证据，可能会从适当治疗中受益。
