Evans E A
Biophys J. 1973 Sep;13(9):926-40. doi: 10.1016/S0006-3495(73)86035-7.
The proposition is made that the red cell membrane is a two-dimensional, incompressible material and a general stress-strain law is developed for finite deformations. In the linear form, the character of such a material is analogous to a two-dimensional Mooney material (e.g., rubber), indicating that the molecular structure in the plane of the membrane would consist of long chains, randomly kinked and cross-linked in the natural state. The loose network could be provided by the protein component and the lipid phase could exist interstitially as a liquid bilayer, giving the membrane its two-dimensional incompressibility. The material provides the capability of large deformations exhibited by the discocyte and yet the rigidity associated with the osmotic spherocyte state. It is demonstrated that a membrane of this type can form a sphere at constant area. An illustrative example of the application to single cell discocyte-to-osmotic spherocyte transformations is presented.
本文提出红细胞膜是一种二维不可压缩材料，并推导了适用于有限变形的一般应力-应变定律。在线性形式下，这种材料的特性类似于二维穆尼材料（如橡胶），这表明膜平面内的分子结构由长链组成，在自然状态下随机扭结并交联。松散的网络可以由蛋白质成分提供，脂质相可以作为液体双层间隙存在，赋予膜二维不可压缩性。这种材料具有盘状红细胞所表现出的大变形能力，以及与渗透球形红细胞状态相关的刚性。结果表明，这种类型的膜可以在恒定面积下形成球体。文中给出了一个将其应用于单细胞盘状红细胞向渗透球形红细胞转变的示例。
