Jensen G F, Christiansen C, Transbøl I
Obstet Gynecol. 1982 Oct;60(4):493-6.
Two hundred eighty-five normal 70-year-old Danish women were divided according to postmenopausal use of gonadal hormones into 3 groups: 1 virtually untreated (3 months or less, N = 231), 1 treated over a short term (4 months to 6 years, N = 36), and 1 treated over a long term (6 years or more, N = 18). The 3 groups had been treated for a median of 0, 6, and 70%, respectively, of their postmenopausal years. The degree of bone loss varied inversely with the duration of postmenopausal hormone treatment. Bone mineral content was 11.8% higher in the long-term treated group than in the untreated group (P less than .05). Likewise, the metacarpal bone mass was 8.5% greater (P less than .01). The number of women with postmenopausal fractures was 13% lower in the long-term treated group than in the untreated group (Difference not significant). Data from this retrospective study present evidence that estrogen protects bones in elderly women.
285名70岁的丹麦正常绝经后女性根据其绝经后性腺激素的使用情况被分为3组：1组几乎未接受治疗（3个月或更短时间，N = 231），1组短期接受治疗（4个月至6年，N = 36），1组长期接受治疗（6年或更长时间，N = 18）。这3组女性在绝经后的时间里接受治疗的中位数分别为0%、6%和70%。骨质流失的程度与绝经后激素治疗的持续时间呈负相关。长期治疗组的骨矿物质含量比未治疗组高11.8%（P <.05）。同样，掌骨质量大8.5%（P <.01）。长期治疗组绝经后骨折的女性人数比未治疗组低13%（差异不显著）。这项回顾性研究的数据表明雌激素对老年女性的骨骼有保护作用。
