Guadagna S, Barattini D F, Rosu S, Ferini-Strambi L
Opera Contract Research Organization Srl, A TIGERMED Company, Timisoara, Romania.
University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
Evid Based Complement Alternat Med. 2020 Apr 21;2020:3792390. doi: 10.1155/2020/3792390. eCollection 2020.
Sleep complaints are common health issues in the general population. These conditions are associated with poorer physical and psychological activity, and they may have important social, economic, and personal consequences. In the last years, several food supplements with different plant extracts have been developed and are currently taken for improving sleep. . The aim of this study is to systematically review recent literature on oral plant extracts acting on sleep disorders distinguishing their action on the different symptoms of sleep complaints: difficulty in initiating or maintaining sleep, waking up too early, and quality of sleep.
We searched the PubMed database up to 05/03/2020 based on data from randomized, double-blind, placebo-controlled trials, noncontrolled trials, and cohort studies conducted in children and adult subjects. The search words used contained the following terms: oral food supplement and sleep disorders and the like. The most studied compounds were further analyzed with a second search using the following terms: name of the compound and sleep disorders. We selected 7 emerging compounds and 38 relevant reports.
Although nutraceutical natural products have been used for sleep empirically, there is a scarcity of evidence on the efficacy of each product in clinical studies. Valerian and lavender were the most frequently studied plant extracts, and their use has been associated (with conflicting results) with anxiolytic effects and improvements in quality and duration of sleep.
Sleep aids based on plant extracts are generally safe and well tolerated by the population. More high-quality research is needed to confirm the effectiveness of food supplements containing plant extracts in sleep complaints; in particular, it would be interesting to evaluate the association between plant extracts and sleep hygiene guidelines and to identify the optimal products to be used in a specific symptom of sleep complaint, giving more appropriate tools to the medical doctor.
睡眠问题是普通人群中常见的健康问题。这些情况与较差的身体和心理活动有关，可能会产生重要的社会、经济和个人后果。近年来，几种含有不同植物提取物的食品补充剂已被开发出来，目前被用于改善睡眠。本研究的目的是系统回顾近期关于作用于睡眠障碍的口服植物提取物的文献，区分它们对睡眠问题不同症状的作用：入睡困难或维持睡眠困难、过早醒来以及睡眠质量。
我们根据在儿童和成人受试者中进行的随机、双盲、安慰剂对照试验、非对照试验和队列研究的数据，检索了截至2020年3月5日的PubMed数据库。使用的检索词包括：口服食品补充剂和睡眠障碍等。对研究最多的化合物进行了进一步分析，第二次检索使用了以下术语：化合物名称和睡眠障碍。我们选择了7种新兴化合物和38篇相关报告。
尽管营养保健品天然产品已被凭经验用于改善睡眠，但临床研究中关于每种产品疗效的证据却很少。缬草和薰衣草是研究最频繁的植物提取物，它们的使用与抗焦虑作用以及睡眠质量和时长的改善有关（结果存在矛盾）。
基于植物提取物的助眠产品总体上是安全的，且人群耐受性良好。需要更多高质量的研究来证实含有植物提取物的食品补充剂对睡眠问题的有效性；特别是，评估植物提取物与睡眠卫生指南之间的关联，并确定用于特定睡眠问题症状的最佳产品，从而为医生提供更合适的工具，将是很有意义的。
