Finklestein S, Miller A, Callahan R J, Fallon J T, Godley F, Feldman B L, Hinton R C, Roberts A B, Strauss H W, Lees R S
Radiology. 1982 Oct;145(1):155-9. doi: 10.1148/radiology.145.1.7122873.
The relationship between degree of acute arterial injury, extent of platelet deposition, and ability to visualize arterial injury with Indium 111-labeled platelets was studied in 18 rabbits. An aortic lesion was made with a balloon catheter in each animal immediately after injection of autologously labeled platelets. Three nonlesioned rabbits with 111In-labeled platelets served as controls. An additional control study was performed in 12 lesioned rabbits in which nine were injected with 111In-labeled plasma protein and three with 111In-labeled red blood cells. A postmortem scanning electron microscope study of the aortae was made to determine the degree of injury to the intima and the amount of platelet deposition on the damaged arterial wall. The radionuclide scans and scanning electron micrographs were then compared. Lesions were seen in ten of 18 animals with labeled platelets that had extensive regions of denuded endothelium covered by a contiguous layer of platelets. Lesions consisting of patchy deendothelialization and platelet deposition could not be visualized on the scans. Red blood cells and fibrin were not conspicuous on micrographs of the lesions. No lesions were visualized in animals receiving 111In-labeled plasma protein or red blood cells before arterial injury, despite platelet deposition in the lesions.
在18只兔子身上研究了急性动脉损伤程度、血小板沉积范围与用铟111标记的血小板可视化动脉损伤能力之间的关系。在每只动物注射自体标记的血小板后，立即用球囊导管造成主动脉损伤。三只注射了铟111标记血小板的未损伤兔子作为对照。对另外12只损伤兔子进行了一项对照研究，其中9只注射了铟111标记的血浆蛋白，3只注射了铟111标记的红细胞。对主动脉进行死后扫描电子显微镜研究，以确定内膜损伤程度和受损动脉壁上的血小板沉积量。然后比较放射性核素扫描和扫描电子显微镜照片。在18只注射了标记血小板的动物中，有10只出现了病变，其内皮剥脱的广泛区域被一层连续的血小板覆盖。由片状内皮剥脱和血小板沉积组成的病变在扫描中无法看到。在病变的显微镜照片中，红细胞和纤维蛋白并不明显。在动脉损伤前接受铟111标记血浆蛋白或红细胞的动物中，尽管病变中有血小板沉积，但未发现病变。
