甲硝唑的两种主要氧化代谢产物对脆弱拟杆菌及相关菌种的体外活性。
In vitro activity of the two principal oxidative metabolites of metronidazole against Bacteroides fragilis and related species.
作者信息
Haller I
出版信息
Antimicrob Agents Chemother. 1982 Jul;22(1):165-6. doi: 10.1128/AAC.22.1.165.
Abstract
Metronidazole and its two principal oxidative metabolites were tested in vitro against 20 clinical isolates of the Bacteroides fragilis group. Both metabolites were bactericidal, and the exhibited 65 and 5%, respectively, of the inhibitory effect of metronidazole. Additive or weak synergistic effects resulted in combination with the parent compound.
摘要
甲硝唑及其两种主要氧化代谢产物在体外针对20株脆弱拟杆菌属临床分离株进行了测试。两种代谢产物均具有杀菌作用，其抑菌作用分别为甲硝唑的65%和5%。与母体化合物联合使用时产生相加或弱协同作用。
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