Rubenson A, Rosetzsky A
Eur J Clin Pharmacol. 1986;29(5):625-8. doi: 10.1007/BF00635904.
Plasma metronidazole was measured following a single intravenous dose of 20 mg/kg (Flagyl 5 mg/ml) in 12 infants less than 1 year of age undergoing abdominal surgery. In all patients sufficient plasma concentrations, well above the MIC values for anaerobic bacteria, were found for at least 16 h. A prolonged half-life was demonstrated in the group less than 8 weeks of age (t1/2/18.4 h). The group over 8 weeks of age demonstrated a t1/2 comparable to that seen in adults (t1/2 7 h).
对12名1岁以下接受腹部手术的婴儿单次静脉注射20mg/kg（甲硝唑5mg/ml）后测定血浆甲硝唑浓度。在所有患者中，发现至少16小时内血浆浓度充足，远高于厌氧菌的最低抑菌浓度值。8周龄以下组显示半衰期延长（t1/2为18.4小时）。8周龄以上组的半衰期与成人相似（t1/2为7小时）。
