Ataullakhanov A I, Ataullakhanov F I, Vitvitskiĭ V M, Zhabotinskiĭ A M, Pichugin A V
Biokhimiia. 1982 Aug;47(8):1293-8.
The regulatory properties of glycolysis in sheep erythrocytes (i. e. dependence of the rate of glucose uptake on ATP concentration) were investigated. A decrease of ATP concentration in the erythrocytes by arsenate causes a sharp rise in the rate of glycolysis, the maximal rate being reached at ATP concentration of about 70% of the original one. Further decrease of ATP lowers the rate of glycolysis; no steady-state rates of energy metabolism are observed within this concentration range. The parameters of glycolysis measured in erythrocytes of various species coincide when the rates of glycolysis are normalized in terms of its maximal value and that of ATP -- in terms of its value at which the maximal rate is reached. The identities of regulatory properties of glycolysis take place even upon two-fold differences in the absolute values of rates and concentrations.
对绵羊红细胞糖酵解的调节特性（即葡萄糖摄取速率对ATP浓度的依赖性）进行了研究。砷酸盐使红细胞中ATP浓度降低，导致糖酵解速率急剧上升，在ATP浓度约为原来的70%时达到最大速率。ATP浓度进一步降低会降低糖酵解速率；在此浓度范围内未观察到能量代谢的稳态速率。当糖酵解速率按其最大值进行归一化处理，而ATP按达到最大速率时的值进行归一化处理时，在不同物种红细胞中测得的糖酵解参数是一致的。即使速率和浓度的绝对值存在两倍差异，糖酵解的调节特性仍相同。
