通过葡萄糖介导的肿瘤选择性pH降低使克隆性恶性细胞对热疗敏感。
Sensitization of clonogenic malignant cells to hyperthermia by glucose-mediated, tumor-selective pH reduction.
作者信息
Jähde E, Rajewsky M F
出版信息
J Cancer Res Clin Oncol. 1982;104(1-2):23-30. doi: 10.1007/BF00402050.
Abstract
The fraction of clonogenic cells (as assayed by colony formation in semisolid agar medium) in neurogenic TV1A tumor transplants carried subcutaneously by hyperglycemic BDIX rats (serum glucose concentration 50 mmoles/1; average intratumoral pH 6.1) was reduced by a factor of approximately 2.5 X 10(3) after in vivo exposure to 42.2 degrees C for 1 h. The corresponding reduction factor for TV1A tumors in normoglycemic rats was about 20 (serum glucose concentration 6 mmoles/1; average intratumoral pH 6.9). Hyperglycemia without hyperthermic treatment reduced clonogenicity by a factor of about 18 ("glucose-mediated suicide").
摘要
高血糖的BDIX大鼠（血清葡萄糖浓度50毫摩尔/升；肿瘤内平均pH值6.1）皮下携带的神经源性TV1A肿瘤移植瘤中的克隆细胞分数（通过半固体琼脂培养基中的集落形成测定），在体内暴露于42.2℃1小时后降低了约2.5×10³倍。正常血糖大鼠的TV1A肿瘤的相应降低倍数约为20（血清葡萄糖浓度6毫摩尔/升；肿瘤内平均pH值6.9）。未经热疗的高血糖使克隆形成能力降低了约18倍（“葡萄糖介导的自杀”）。
相似文献
1
Sensitization of clonogenic malignant cells to hyperthermia by glucose-mediated, tumor-selective pH reduction.通过葡萄糖介导的肿瘤选择性pH降低使克隆性恶性细胞对热疗敏感。
J Cancer Res Clin Oncol. 1982;104(1-2):23-30. doi: 10.1007/BF00402050.
2
3
Acute changes of systemic parameters in tumour-bearing rats, and of tumour glucose, lactate, and ATP levels upon local hyperthermia and/or hyperglycaemia.荷瘤大鼠全身参数的急性变化，以及局部热疗和/或高血糖时肿瘤的葡萄糖、乳酸和ATP水平的变化。
J Cancer Res Clin Oncol. 1991;117(5):409-15. doi: 10.1007/BF01612759.
4
Microregional distributions of glucose, lactate, ATP and tissue pH in experimental tumours upon local hyperthermia and/or hyperglycaemia.局部热疗和/或高血糖症作用下实验性肿瘤中葡萄糖、乳酸、三磷酸腺苷及组织pH的微区分布
J Cancer Res Clin Oncol. 1993;119(10):599-608. doi: 10.1007/BF01372723.
5
Laser Doppler flux and tissue oxygenation of experimental tumours upon local hyperthermia and/or hyperglycaemia.局部热疗和/或高血糖情况下实验性肿瘤的激光多普勒血流及组织氧合
J Cancer Res Clin Oncol. 1992;118(7):523-8. doi: 10.1007/BF01225267.
6
Circulatory and metabolic responses of malignant tumors during localized hyperthermia.局部热疗期间恶性肿瘤的循环和代谢反应
J Cancer Res Clin Oncol. 1980;98(1):15-29. doi: 10.1007/BF00413173.
7
Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling.用于管理1型糖尿病患者血糖水平的混合闭环系统：系统评价与经济建模
Health Technol Assess. 2024 Dec;28(80):1-190. doi: 10.3310/JYPL3536.
8
Experimental chemotherapy with N'N'-bis(2-chloroethyl)-N-nitrosourea (BCNU) in autochthonous neurogenic tumors of the rat transplacentally induced by ethylnitrosourea.用N'N'-双（2-氯乙基）-N-亚硝基脲（卡莫司汀）对经乙基亚硝基脲经胎盘诱导的大鼠自发性神经源性肿瘤进行实验性化疗。
J Cancer Res Clin Oncol. 1982;104(1-2):89-98. doi: 10.1007/BF00402057.
9
Mechanism of heat treatment on exercise pressor reflex in hindlimb ischemia-reperfusion: Does the temperature gradient matter?热处理对后肢缺血再灌注运动升压反射的作用机制：温度梯度重要吗？
Auton Neurosci. 2025 Jun;259:103290. doi: 10.1016/j.autneu.2025.103290. Epub 2025 May 15.
10
Wenjing decoction exerts analgesic effects on cold coagulation and stasis PD through BDNF/ TRKB/CREB pathway.温经汤通过BDNF/TRKB/CREB通路对寒凝血瘀型原发性痛经发挥镇痛作用。
J Ethnopharmacol. 2025 Jul 3;352:120220. doi: 10.1016/j.jep.2025.120220.
引用本文的文献
1
In vivo metabolic effects of hyperglycemia in murine radiation-induced fibrosarcoma: a 31P NMR investigation.小鼠辐射诱导纤维肉瘤中高血糖的体内代谢效应：一项31P核磁共振研究。
Proc Natl Acad Sci U S A. 1984 Oct;81(20):6496-500. doi: 10.1073/pnas.81.20.6496.
本文引用的文献
1
THE INTERSTITIAL FLUID OF SOLID TUMORS.实体肿瘤的间质液
Cancer Res. 1964 Jun;24:780-94.
2
3
pH-sensitive liposomes: possible clinical implications.pH敏感脂质体：可能的临床意义。
Science. 1980 Dec 12;210(4475):1253-5. doi: 10.1126/science.7434025.
4
Selective inhibition of microcirculation in tumor tissue.
Naturwissenschaften. 1980 Mar;67(3):154. doi: 10.1007/BF01073629.
5
The effect of pH on cell lethality induced by hyperthermic treatment.pH对热疗诱导的细胞致死率的影响。
Cancer. 1980 May 1;45(9):2291-2300. doi: 10.1002/1097-0142(19800501)45:9<2291::aid-cncr2820450912>3.0.co;2-x.
6
Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma.C3H小鼠乳腺腺癌中氧分压和pH值的异质性分布
Cancer Res. 1981 May;41(5):2008-13.
7
8
pH distributions in transplanted neural tumors and normal tissues of BDIX rats as measured with pH microelectrodes.用pH微电极测量BDIX大鼠移植神经肿瘤和正常组织中的pH分布。
Cancer Res. 1982 Apr;42(4):1498-504.
9
Effects of hyperthermia on a neurogenic rat cell line (BT4C) in culture. Development of thermal tolerance during continuous heating.
Acta Radiol Oncol. 1980;19(6):489-96. doi: 10.3109/02841868009130181.
10
[Respiratory gas exchange and glucose metabolism of tumors (DS-carcinosarcoma) in vivo. I. Experimental investigations of the parameters determining the supply conditions].
Z Gesamte Exp Med Einschl Exp Chir. 1971;156(4):283-94.
Zotero 插件