通过葡萄糖介导的肿瘤选择性pH降低使克隆性恶性细胞对热疗敏感。
Sensitization of clonogenic malignant cells to hyperthermia by glucose-mediated, tumor-selective pH reduction.
作者信息
Jähde E, Rajewsky M F
出版信息
J Cancer Res Clin Oncol. 1982;104(1-2):23-30. doi: 10.1007/BF00402050.
Abstract
The fraction of clonogenic cells (as assayed by colony formation in semisolid agar medium) in neurogenic TV1A tumor transplants carried subcutaneously by hyperglycemic BDIX rats (serum glucose concentration 50 mmoles/1; average intratumoral pH 6.1) was reduced by a factor of approximately 2.5 X 10(3) after in vivo exposure to 42.2 degrees C for 1 h. The corresponding reduction factor for TV1A tumors in normoglycemic rats was about 20 (serum glucose concentration 6 mmoles/1; average intratumoral pH 6.9). Hyperglycemia without hyperthermic treatment reduced clonogenicity by a factor of about 18 ("glucose-mediated suicide").
摘要
高血糖的BDIX大鼠（血清葡萄糖浓度50毫摩尔/升；肿瘤内平均pH值6.1）皮下携带的神经源性TV1A肿瘤移植瘤中的克隆细胞分数（通过半固体琼脂培养基中的集落形成测定），在体内暴露于42.2℃1小时后降低了约2.5×10³倍。正常血糖大鼠的TV1A肿瘤的相应降低倍数约为20（血清葡萄糖浓度6毫摩尔/升；肿瘤内平均pH值6.9）。未经热疗的高血糖使克隆形成能力降低了约18倍（“葡萄糖介导的自杀”）。
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