Sensitization of clonogenic malignant cells to hyperthermia by glucose-mediated, tumor-selective pH reduction.
作者信息
Jähde E, Rajewsky M F
出版信息
J Cancer Res Clin Oncol. 1982;104(1-2):23-30. doi: 10.1007/BF00402050.
Abstract
The fraction of clonogenic cells (as assayed by colony formation in semisolid agar medium) in neurogenic TV1A tumor transplants carried subcutaneously by hyperglycemic BDIX rats (serum glucose concentration 50 mmoles/1; average intratumoral pH 6.1) was reduced by a factor of approximately 2.5 X 10(3) after in vivo exposure to 42.2 degrees C for 1 h. The corresponding reduction factor for TV1A tumors in normoglycemic rats was about 20 (serum glucose concentration 6 mmoles/1; average intratumoral pH 6.9). Hyperglycemia without hyperthermic treatment reduced clonogenicity by a factor of about 18 ("glucose-mediated suicide").
摘要
相似文献
1
Sensitization of clonogenic malignant cells to hyperthermia by glucose-mediated, tumor-selective pH reduction.
J Cancer Res Clin Oncol. 1982;104(1-2):23-30. doi: 10.1007/BF00402050.
2
Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues.
Cancer Res. 1982 Apr;42(4):1505-12.
3
Acute changes of systemic parameters in tumour-bearing rats, and of tumour glucose, lactate, and ATP levels upon local hyperthermia and/or hyperglycaemia.
J Cancer Res Clin Oncol. 1991;117(5):409-15. doi: 10.1007/BF01612759.
4
Microregional distributions of glucose, lactate, ATP and tissue pH in experimental tumours upon local hyperthermia and/or hyperglycaemia.
J Cancer Res Clin Oncol. 1993;119(10):599-608. doi: 10.1007/BF01372723.
5
Laser Doppler flux and tissue oxygenation of experimental tumours upon local hyperthermia and/or hyperglycaemia.
J Cancer Res Clin Oncol. 1992;118(7):523-8. doi: 10.1007/BF01225267.
6
Circulatory and metabolic responses of malignant tumors during localized hyperthermia.
J Cancer Res Clin Oncol. 1980;98(1):15-29. doi: 10.1007/BF00413173.
7
Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling.
Health Technol Assess. 2024 Dec;28(80):1-190. doi: 10.3310/JYPL3536.
8
Experimental chemotherapy with N'N'-bis(2-chloroethyl)-N-nitrosourea (BCNU) in autochthonous neurogenic tumors of the rat transplacentally induced by ethylnitrosourea.
J Cancer Res Clin Oncol. 1982;104(1-2):89-98. doi: 10.1007/BF00402057.
9
Mechanism of heat treatment on exercise pressor reflex in hindlimb ischemia-reperfusion: Does the temperature gradient matter?
Auton Neurosci. 2025 Jun;259:103290. doi: 10.1016/j.autneu.2025.103290. Epub 2025 May 15.
10
Wenjing decoction exerts analgesic effects on cold coagulation and stasis PD through BDNF/ TRKB/CREB pathway.
J Ethnopharmacol. 2025 Jul 3;352:120220. doi: 10.1016/j.jep.2025.120220.
引用本文的文献
1
In vivo metabolic effects of hyperglycemia in murine radiation-induced fibrosarcoma: a 31P NMR investigation.
Proc Natl Acad Sci U S A. 1984 Oct;81(20):6496-500. doi: 10.1073/pnas.81.20.6496.
本文引用的文献
1
THE INTERSTITIAL FLUID OF SOLID TUMORS.
Cancer Res. 1964 Jun;24:780-94.
2
Effect of hyperglycemia on blood flow, pH, and response to hyperthermia (42 degrees) of the Yoshida sarcoma in the rat.
Cancer Res. 1980 Dec;40(12):4728-33.
3
pH-sensitive liposomes: possible clinical implications.
Science. 1980 Dec 12;210(4475):1253-5. doi: 10.1126/science.7434025.
4
Selective inhibition of microcirculation in tumor tissue.
Naturwissenschaften. 1980 Mar;67(3):154. doi: 10.1007/BF01073629.
5
The effect of pH on cell lethality induced by hyperthermic treatment.
Cancer. 1980 May 1;45(9):2291-2300. doi: 10.1002/1097-0142(19800501)45:9<2291::aid-cncr2820450912>3.0.co;2-x.
6
Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma.
Cancer Res. 1981 May;41(5):2008-13.
7
Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues.
Cancer Res. 1982 Apr;42(4):1505-12.
8
pH distributions in transplanted neural tumors and normal tissues of BDIX rats as measured with pH microelectrodes.
Cancer Res. 1982 Apr;42(4):1498-504.
9
Effects of hyperthermia on a neurogenic rat cell line (BT4C) in culture. Development of thermal tolerance during continuous heating.
Acta Radiol Oncol. 1980;19(6):489-96. doi: 10.3109/02841868009130181.
10
[Respiratory gas exchange and glucose metabolism of tumors (DS-carcinosarcoma) in vivo. I. Experimental investigations of the parameters determining the supply conditions].
Z Gesamte Exp Med Einschl Exp Chir. 1971;156(4):283-94.
Zotero 插件