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[高龄糖尿病。3. 与新诊断的晚发性糖尿病患者相比,老年长期糖尿病患者的心血管风险模式]

[Diabetes mellitus in advanced old age. 3. Cardiovascular risk patterns in long-term diabetics who have grown old compared to newly detected cases of late-onset diabetics].

作者信息

Schneider H, Pastow A

出版信息

Z Alternsforsch. 1982 Jul-Aug;37(4):267-72.

PMID:7136019
Abstract

The investigation of each 131 long term diabetics of 60 years and older (average: 71 years) with a mean diabetes duration of 19.7 years with respect to the presence of 5 classical risk factors of the "metabolic syndrome" yielded a significant more seldom appearance of hypertension and overweight (p less than 0.01) in comparison to newly detected old age diabetics (group comparison done with the principle of biostatical gemini forming), while the frequencies of hypercholesterolemia, hypertriglyceridemia and hyperuricemia didn't differ in the two groups. Though the cardio-vascular risk profile of the long term diabetics (mean value: 2.28 risk factors per patient) shows more favourable with this (selection by overmortality of diabetics with several risk factors already with shorter disease duration?) than with newly detected diabetic patients (mean value: 2.85 risk factors per patient) is demanded on account of the negative influence of the cardiovascular risk factors on the development of macroangiopathy to mind these pathogenic magnitudes of influence also with longer duration of the diabetes stronger than before now in higher ages too.

摘要

对131名60岁及以上的长期糖尿病患者(平均年龄:71岁)进行调查,这些患者的糖尿病平均病程为19.7年,调查其是否存在“代谢综合征”的5种经典风险因素。结果显示,与新诊断的老年糖尿病患者相比(采用生物统计学配对原则进行组间比较),高血压和超重的出现频率显著更低(p<0.01),而两组中高胆固醇血症、高甘油三酯血症和高尿酸血症的频率并无差异。尽管长期糖尿病患者的心血管风险状况(平均值:每位患者2.28个风险因素)比新诊断的糖尿病患者(平均值:每位患者2.85个风险因素)更有利(是否是通过对病程较短时就已有多种风险因素的糖尿病患者进行超额死亡率筛选?),但考虑到心血管风险因素对大血管病变发展的负面影响,在糖尿病病程较长时,即使在更高年龄,也应比现在更重视这些致病影响因素。

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