Tenk I, Fodor E, Szathmáry C
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1982 Jul;252(3):384-93.
The gut microflora and adrenal cortex hormone levels were monitored in HUNGAHYB piglets of 10-12 kg and in Wistar rats of 100-150 g body weight fed with different pure Fusarium toxins. The feeding of either T-2, T-2 + F-2 and DAS toxins at the 5 microgram/g feed level for one week resulted in the substantial increase of aerobic bacteria count of the intestine. Increase of the DAS dose to a twofold level failed to elicit dose-response and no further increases in bacterial counts were observed. Following the uptake of toxin containing feed, the plasma cortisol and corticosterone levels showed a 2-3 fold rise. Intramuscular administration of toxin T-2 also increased the activity of the adrenal cortex and gut microflora counts also increased. It is suggested that the observed changes in the gut microflora may contribute to the appearance of clinical symptoms developing after feeding of toxins as well as to the triggering and maintaining of the stress.
对体重10 - 12千克的HUNGAHYB仔猪和体重100 - 150克的Wistar大鼠喂食不同的纯镰刀菌毒素，监测其肠道微生物群和肾上腺皮质激素水平。以5微克/克饲料水平喂食T - 2、T - 2 + F - 2和DAS毒素一周，导致肠道需氧菌数量大幅增加。将DAS剂量增加到两倍水平未能引发剂量反应，未观察到细菌数量进一步增加。摄入含毒素饲料后，血浆皮质醇和皮质酮水平升高了2 - 3倍。肌肉注射毒素T - 2也增加了肾上腺皮质的活性，肠道微生物群数量也增加。提示所观察到的肠道微生物群变化可能导致喂食毒素后出现的临床症状，以及应激的触发和维持。
