Kryzhanovskaia E G
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1982;5(2):35-41.
In tests on cats with cut vagus and aortal nerves, clipped common carotid arteries caused a sharp increase in sympathic activity (SA) in the cardiac nerves, a rise of arterial pressure (AP) and ventricular arrhythmias. Lithium chloride and hydroxibutirate injected intravenously reduced SA, AP and restored sinus rhythm. While administering arrhythmogenic doses of strophantin R, similar rhythm disturbances were observed in addition to increase in SA in animals with denervated cardio-aortal and sinocarotid areas. In these cases lithium drugs also had an antiarrhythmic action and reduced SA. In cats with the preserved innervation of the above reflexogenic sites, reflexogenic sites, strophantine arrythmias developed against the background of SA reduction and lithium drugs were inefficacious. In experiments on rats, while injecting large doses of intravenous adrenalin secondary ventricular rhythm disturbances have been shown to occur 1-1.5 min after the drug injection and to result in death, Lithium chloride and hydroxibutirate prevent the development of these arrhythmias and the animals' death.
在对切断迷走神经和主动脉神经的猫进行的实验中，钳夹颈总动脉会导致心脏神经中的交感神经活动（SA）急剧增加、动脉血压（AP）升高以及室性心律失常。静脉注射氯化锂和羟基丁酸可降低SA、AP并恢复窦性心律。在给予致心律失常剂量的毒毛花苷R时，除了去神经的心主动脉和窦颈动脉区域的动物SA增加外，还观察到类似的节律紊乱。在这些情况下，锂药物也具有抗心律失常作用并降低SA。在上述反射源部位神经支配保留的猫中，反射源部位的毒毛花苷心律失常是在SA降低的背景下发生的，锂药物无效。在对大鼠的实验中，静脉注射大剂量肾上腺素后，已证明在药物注射后1 - 1.5分钟会出现继发性室性节律紊乱并导致死亡，氯化锂和羟基丁酸可预防这些心律失常的发生以及动物死亡。
