Wald A, Van Thiel D H, Hoechstetter L, Gavaler J S, Egler K M, Verm R, Scott L, Lester R
Dig Dis Sci. 1982 Nov;27(11):1015-8. doi: 10.1007/BF01391748.
In order to evaluate the possible effects of pregnancy-associated sex steroids on gastrointestinal function, we determined gastrointestinal transit times and sex steroid levels in 15 women during the third trimester of their pregnancies and again 4--6 weeks following delivery when gastrointestinal function had symptomatically returned to normal. Gastrointestinal transit time from ingestion of a liquid lactulose meal to its delivery to the cecum was determined by monitoring breath hydrogen concentrations at 10-min intervals. Gastrointestinal transit times were significantly prolonged in the third trimester of pregnancy, when progesterone and estradiol levels were increased, compared to the postpartum period. This study supports previous findings which suggest that increasing levels of progesterone and estradiol affect gastrointestinal function and therefore may contribute to gastrointestinal symptoms that often occur in pregnant women.
为了评估妊娠相关性激素对胃肠功能的可能影响，我们测定了15名妇女在妊娠晚期以及产后4 - 6周（此时胃肠功能在症状上已恢复正常）的胃肠转运时间和性激素水平。通过每隔10分钟监测呼气中氢气浓度来测定从摄入液体乳果糖餐到其到达盲肠的胃肠转运时间。与产后时期相比，妊娠晚期孕酮和雌二醇水平升高时，胃肠转运时间显著延长。这项研究支持了先前的研究结果，即孕酮和雌二醇水平的升高会影响胃肠功能，因此可能导致孕妇经常出现的胃肠道症状。
