Katz S M, Habib W A, Hammel J M, Nash P
Infect Immun. 1982 Nov;38(2):620-2. doi: 10.1128/iai.38.2.620-622.1982.
Many investigators find no spread of Legionnaires disease from person to person. The present study examined the question of airborne transmission of infection by Legionella pneumophila serogroup 1 from guinea pigs inoculated nasally with the agent to healthy guinea pigs. The nasal inoculation produced confluent peribronchiolar pneumonia similar to the pulmonary lesions observed in humans, but by techniques of clinical observation, serology, culture, and pathology, there was no evidence of airborne spread of infection from 26 inoculated guinea pigs to 64 uninoculated guinea pigs. The results, compatible with epidemiological studies of Legionnaires disease that fail to demonstrate airborne person-to-person transmission of the illness in humans, are useful for scientists who work with animal models of Legionnaires disease.
许多研究者发现军团病不会在人与人之间传播。本研究探讨了从经鼻腔接种嗜肺军团菌血清型1的豚鼠向健康豚鼠进行空气传播感染的问题。鼻腔接种产生了与人类观察到的肺部病变相似的融合性细支气管周围肺炎，但通过临床观察、血清学、培养和病理学技术，没有证据表明从26只接种的豚鼠向64只未接种的豚鼠发生空气传播感染。这些结果与军团病的流行病学研究结果一致，该研究未能证明人类疾病通过空气在人与人之间传播，对从事军团病动物模型研究的科学家有用。
