豚鼠之间不存在嗜肺军团菌通过空气传播感染的情况。
Lack of airborne spread of infection by Legionella pneumophila among guinea pigs.
作者信息
Katz S M, Habib W A, Hammel J M, Nash P
出版信息
Infect Immun. 1982 Nov;38(2):620-2. doi: 10.1128/iai.38.2.620-622.1982.
Abstract
Many investigators find no spread of Legionnaires disease from person to person. The present study examined the question of airborne transmission of infection by Legionella pneumophila serogroup 1 from guinea pigs inoculated nasally with the agent to healthy guinea pigs. The nasal inoculation produced confluent peribronchiolar pneumonia similar to the pulmonary lesions observed in humans, but by techniques of clinical observation, serology, culture, and pathology, there was no evidence of airborne spread of infection from 26 inoculated guinea pigs to 64 uninoculated guinea pigs. The results, compatible with epidemiological studies of Legionnaires disease that fail to demonstrate airborne person-to-person transmission of the illness in humans, are useful for scientists who work with animal models of Legionnaires disease.
摘要
许多研究者发现军团病不会在人与人之间传播。本研究探讨了从经鼻腔接种嗜肺军团菌血清型1的豚鼠向健康豚鼠进行空气传播感染的问题。鼻腔接种产生了与人类观察到的肺部病变相似的融合性细支气管周围肺炎，但通过临床观察、血清学、培养和病理学技术，没有证据表明从26只接种的豚鼠向64只未接种的豚鼠发生空气传播感染。这些结果与军团病的流行病学研究结果一致，该研究未能证明人类疾病通过空气在人与人之间传播，对从事军团病动物模型研究的科学家有用。
相似文献
1
Lack of airborne spread of infection by Legionella pneumophila among guinea pigs.豚鼠之间不存在嗜肺军团菌通过空气传播感染的情况。
Infect Immun. 1982 Nov;38(2):620-2. doi: 10.1128/iai.38.2.620-622.1982.
2
Legionella pneumophila contamination of a hospital humidifier. Demonstration of aerosol transmission and subsequent subclinical infection in exposed guinea pigs.医院加湿器中的嗜肺军团菌污染。暴露豚鼠气溶胶传播及后续亚临床感染的证明。
Am Rev Respir Dis. 1983 Oct;128(4):657-61. doi: 10.1164/arrd.1983.128.4.657.
3
Legionella pneumonia in guinea pigs exposed to aerosols of concentrated potable water from a hospital with nosocomial Legionnaires' disease.在一家发生医院内军团病的医院中，将豚鼠暴露于浓缩饮用水气溶胶下引发的军团菌肺炎
J Infect Dis. 1983 Jan;147(1):129-32. doi: 10.1093/infdis/147.1.129.
4
Experimental transmission of legionnaires' disease by exposure to aerosols of Legionella pneumophila.通过暴露于嗜肺军团菌气溶胶进行军团病的实验性传播。
Lancet. 1981;2(8260-61):1389-90. doi: 10.1016/s0140-6736(81)92803-8.
5
Pontiac fever: isolation of the etiologic agent (Legionella pneumophilia) and demonstration of its mode of transmission.庞蒂亚克热：病原体（嗜肺军团菌）的分离及其传播方式的证明。
Am J Epidemiol. 1981 Sep;114(3):337-47. doi: 10.1093/oxfordjournals.aje.a113200.
6
Legionnaires' pneumonia after aerosol exposure in guinea pigs and rats.豚鼠和大鼠经气溶胶暴露后发生军团菌肺炎。
Am Rev Respir Dis. 1982 Dec;126(6):1050-7. doi: 10.1164/arrd.1982.126.6.1050.
7
A self-limited febrile illness produced in guinea pigs associated with oral administration of Legionella pneumophila.豚鼠经口服嗜肺军团菌后产生的一种自限性发热性疾病。
Gastroenterology. 1988 Dec;95(6):1575-81. doi: 10.1016/s0016-5085(88)80080-5.
8
Legionella pneumophila in drinking water of guinea pigs.豚鼠饮用水中的嗜肺军团菌。
Ann Intern Med. 1979 Aug;91(2):323. doi: 10.7326/0003-4819-91-2-323_1.
9
Legionellosis: evidence of airborne transmission.军团病：空气传播的证据。
Ann N Y Acad Sci. 1980;353:61-6. doi: 10.1111/j.1749-6632.1980.tb18906.x.
10
Legionnaires' disease: the infective dose paradox.军团病：感染剂量悖论。
Lancet. 1993 Jul 3;342(8862):5-6. doi: 10.1016/0140-6736(93)91877-o.
引用本文的文献
1
Airborne Infectious Agents and Other Pollutants in Automobiles for Domestic Use: Potential Health Impacts and Approaches to Risk Mitigation.家用汽车中的空气传播传染病原体和其他污染物：潜在健康影响及风险缓解方法。
J Environ Public Health. 2016;2016:1548326. doi: 10.1155/2016/1548326. Epub 2016 Nov 30.
2
Activation of host mitogen-activated protein kinases by secreted Legionella pneumophila effectors that inhibit host protein translation.分泌的肺炎军团菌效应物通过抑制宿主蛋白翻译来激活宿主丝裂原活化蛋白激酶。
Infect Immun. 2012 Oct;80(10):3570-5. doi: 10.1128/IAI.00557-12. Epub 2012 Jul 30.
3
Immunology taught by bacteria.细菌教的免疫学。
J Clin Immunol. 2010 Jul;30(4):507-11. doi: 10.1007/s10875-010-9389-2. Epub 2010 Apr 6.
4
Caenorhabditis is a metazoan host for Legionella.秀丽隐杆线虫是军团菌的后生动物宿主。
Cell Microbiol. 2010 Mar;12(3):343-61. doi: 10.1111/j.1462-5822.2009.01398.x. Epub 2009 Oct 27.
5
The guinea pig as a model of infectious diseases.豚鼠作为传染病模型。
Comp Med. 2008 Aug;58(4):324-40.
6
Survival of virulent Legionella pneumophila in aerosols.强毒嗜肺军团菌在气溶胶中的存活情况。
J Hyg (Lond). 1983 Jun;90(3):451-60. doi: 10.1017/s0022172400029090.
本文引用的文献
1
The influence of certain salts, amino acids, sugars, and proteins on the stability of rickettsiae.某些盐类、氨基酸、糖类及蛋白质对立克次氏体稳定性的影响。
J Bacteriol. 1950 Apr;59(4):509-22. doi: 10.1128/jb.59.4.509-522.1950.
2
Hospitals harbor a built-in disease source.医院里隐藏着一个内在的疾病源。
Science. 1980 Nov 14;210(4471):745-6, 748-9. doi: 10.1126/science.7433995.
3
Electron microscopic examination of the inflammatory response to Legionella pneumophila in guinea pigs.豚鼠对嗜肺军团菌炎症反应的电子显微镜检查
Lab Invest. 1982 Jan;46(1):24-32.
4
Legionnaires' disease: a new awareness.军团病：新的认知
Trans Stud Coll Physicians Phila. 1980 Sep;2(3):178-86.
5
A sporadic case of pneumonia due to legionnaires disease.一例由军团病引起的散发性肺炎病例。
Mayo Clin Proc. 1977 Oct;52(10):657-60.
6
The morphology of the Legionnaires' disease organism.军团病病原体的形态学。
Am J Pathol. 1978 Mar;90(3):701-22.
7
Pontiac fever. An epidemic of unknown etiology in a health department: I. Clinical and epidemiologic aspects.庞蒂亚克热。某卫生部门发生的病因不明的流行病：I. 临床和流行病学方面。
Am J Epidemiol. 1978 Feb;107(2):149-60. doi: 10.1093/oxfordjournals.aje.a112517.
8
Prevalence of antibody to the Legionnaires' disease bacterium in hospital employees.医院员工中军团菌病细菌抗体的流行情况。
Ann Intern Med. 1979 Apr;90(4):601-3. doi: 10.7326/0003-4819-90-4-601.
9
Sporadic community-acquired Legionnaires' disease in the United States. A case-control study.美国散发性社区获得性军团病。一项病例对照研究。
Ann Intern Med. 1979 Apr;90(4):596-600. doi: 10.7326/0003-4819-90-4-596.
10
A major focus of Legionnaires' disease in Bloomington, Indiana.
Ann Intern Med. 1979 Apr;90(4):587-91. doi: 10.7326/0003-4819-90-4-587.
Zotero 插件