Nara P L, Davis L E, Lauerman L H, Coyle-Dennis J E, Paul J
J Vet Pharmacol Ther. 1982 Sep;5(3):177-85. doi: 10.1111/j.1365-2885.1982.tb00428.x.
The effect of oral chloramphenicol (CHPC) on the development of immune responses to canine distemper virus (CDV) in Beagle pups was studied. Dogs were treated with CHPC for 14 days at a dose of 50 mg/kg, three times a day. Hematologic changes in CHPC-treated dogs included: polychromasia, anisocytosis, and target cell formation of red blood cells concurrent with vacuolation of lymphocytes and basophilic granule formation in neutrophils. Dogs given this therapy showed normal in vivo and in vitro immune responses after CDV vaccination and survived a virulent CDV challenge, whereas untreated, unvaccinated dogs became ill or died after challenge exposure. The results of this study indicate that CHPC therapy does not interfere with either the prechallenge immune response to attenuated viral antigen or the efficient immune mechanisms invoked during virulent virus challenge.
研究了口服氯霉素（CHPC）对比格幼犬犬瘟热病毒（CDV）免疫反应发育的影响。犬只按50mg/kg的剂量每日三次接受CHPC治疗14天。接受CHPC治疗的犬只血液学变化包括：红细胞多染性、红细胞大小不均以及靶细胞形成，同时伴有淋巴细胞空泡化和嗜中性粒细胞嗜碱性颗粒形成。接受该治疗的犬只在接种CDV疫苗后体内和体外免疫反应均正常，并在强毒CDV攻击后存活，而未治疗、未接种疫苗的犬只在攻击暴露后患病或死亡。本研究结果表明，CHPC治疗既不干扰对减毒病毒抗原的攻击前免疫反应，也不干扰强毒病毒攻击期间调用的有效免疫机制。
