Nara P L, Krakowka S, Powers T E
Am J Vet Res. 1979 Dec;40(12):1742-7.
Effects of oral prednisolone (OP) on the development of immune responses of Beagle pups to canine distemper virus (CDV) were studied. Dogs were treated with OP for 21 days, twice a day for the first 7 days, once a day for the next 7 days, and on alternate days for the last 7 days. Dogs given dosages of OP (1 mg/kg and 10 mg/kg) showed a normal in vivo immunogenic response after CDV vaccination and survived a virulent CDV challenge exposure, whereas non-treated, nonvaccinated dogs became ill or died after challenge exposure. The most marked effect of corticosteroid treatment on the immune system was the graded phytoimmunosuppressive effect upon the lymphocyte blast transformation test.
研究了口服泼尼松龙（OP）对比格幼犬针对犬瘟热病毒（CDV）免疫反应发育的影响。给犬只服用OP 21天，前7天每天两次，接下来7天每天一次，最后7天隔天一次。给予OP剂量为1毫克/千克和10毫克/千克的犬只在接种CDV疫苗后表现出正常的体内免疫原性反应，并在遭受强毒CDV攻击暴露后存活下来，而未治疗、未接种疫苗的犬只在攻击暴露后生病或死亡。皮质类固醇治疗对免疫系统最显著的影响是对淋巴细胞增殖转化试验具有分级的植物免疫抑制作用。
