甲氧苄啶在对空肠弯曲菌有选择性的培养基中的活性。
Trimethoprim activity in media selective for Campylobacter jejuni.
作者信息
Bopp C A, Wells J G, Barrett T J
出版信息
J Clin Microbiol. 1982 Nov;16(5):808-12. doi: 10.1128/jcm.16.5.808-812.1982.
The activity of trimethoprim (TMP) in two selective media used for isolation of Campylobacter jejuni was evaluated. The two selective media, Campy-BAP and Skirrow medium, contain TMP in addition to other antimicrobial agents. The minimal inhibitory concentrations of TMP in blood agar base (basal agar for Skirrow medium) or brucella agar (basal agar for Campy-BAP) for three sensitive control organisms were compared with those in Mueller-Hinton agar, which contains low levels of thymidine. TMP was inactive in both blood agar base and brucella agar, even when lysed horse blood or thymidine phosphorylase was added. TMP had activity when used in combination with the other antimicrobial agents normally included in Skirrow medium and Campy-BAP, probably indicating synergism between TMP and one or more of the other antimicrobial agents. Sheep blood could be substituted for lysed horse blood in Skirrow medium without compromising the activity of TMP.
评估了甲氧苄啶（TMP）在两种用于分离空肠弯曲菌的选择性培养基中的活性。这两种选择性培养基，即弯曲菌血琼脂基础培养基（Campy - BAP）和斯基罗培养基（Skirrow medium），除了其他抗菌剂外还含有TMP。将三种敏感对照菌株在血琼脂基础培养基（斯基罗培养基的基础琼脂）或布鲁氏菌琼脂（Campy - BAP的基础琼脂）中TMP的最低抑菌浓度与在含有低水平胸苷的穆勒 - 欣顿琼脂中的最低抑菌浓度进行了比较。即使添加了溶血马血或胸苷磷酸化酶，TMP在血琼脂基础培养基和布鲁氏菌琼脂中均无活性。当TMP与斯基罗培养基和Campy - BAP中通常包含的其他抗菌剂联合使用时具有活性，这可能表明TMP与一种或多种其他抗菌剂之间存在协同作用。在斯基罗培养基中，羊血可以替代溶血马血而不影响TMP的活性。
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