Blaser M J, Berkowitz I D, LaForce F M, Cravens J, Reller L B, Wang W L
Ann Intern Med. 1979 Aug;91(2):179-85. doi: 10.7326/0003-4819-91-2-179.
Campylobacter fetus subspecies (ssp.) jejuni has been recently recognized to cause diarrheal disease in man. To assess its importance as an enteric pathogen, we prospectively studied 514 patients with diarrhea. Campylobacter fetus ssp. jejuni was isolated from the feces of 26 patients (5%) and seven of 11 of their symptomatic household contacts. This organism was isolated from the feces of only one of 18 asymptomatic household contacts and not at all from 157 other healthy persons. Seventeen of 20 patients from whom C. fetus ssp. jejuni was isolated from fecal culture showed at least a fourfold rise in specific IgG titers. Review of 35 cases of campylobacter enteritis identified a typical clinical syndrome with acute onset of diarrhea, abdominal pain, fever, and constitutional symptoms. Stool examination revealed blood in 60% and polymorphonuclear leukocytes in 78% of patients. Epidemiologic investigation strongly suggested an external source for the infection in 22 of 35 patients.
胎儿弯曲菌空肠亚种最近被认为可导致人类腹泻病。为评估其作为肠道病原体的重要性，我们对514例腹泻患者进行了前瞻性研究。从26例患者（5%）的粪便中分离出胎儿弯曲菌空肠亚种，其11名有症状的家庭接触者中有7人粪便中也分离出该菌。仅从18名无症状家庭接触者中的1人粪便中分离出该菌，而在157名其他健康人中未分离出。粪便培养分离出胎儿弯曲菌空肠亚种的20例患者中，有17例特异性IgG滴度至少升高四倍。回顾35例弯曲菌肠炎病例，确定了一种典型的临床综合征，表现为腹泻、腹痛、发热和全身症状急性发作。粪便检查显示，60%的患者粪便中有血，78%的患者粪便中有多形核白细胞。流行病学调查强烈提示，35例患者中有22例感染有外部来源。
