Matthews P N, Grant A G, Hermon-Taylor J
Urol Res. 1982;10(6):293-9. doi: 10.1007/BF00255876.
Primary human kidney and bladder tumours were implanted into both nude rats (rnu/rnu) and nude mice (nu/nu). 40% of bladder tumours and 27% of kidney tumours were established as xenografts. Histological sections of primary tumour and xenografts confirmed their similarities. Two patients with renal tissues were hypercalcaemic prior to nephrectomy, and animals in which these tumours grew as xenografts also became hypercalcaemic. Cell lines were established in tissue culture from two of the kidney tumour xenografts, and chromosome studies have confirmed their human karyotype.
将原发性人类肾脏和膀胱肿瘤植入裸大鼠（rnu/rnu）和裸小鼠（nu/nu）体内。40%的膀胱肿瘤和27%的肾脏肿瘤成功建立异种移植模型。原发性肿瘤和异种移植瘤的组织学切片证实了它们的相似性。两名患有肾脏组织疾病的患者在肾切除术前出现高钙血症，这些肿瘤作为异种移植瘤生长的动物也出现了高钙血症。从两个肾脏肿瘤异种移植瘤中建立了细胞系，染色体研究证实了它们的人类核型。
