Zvolsky P, Dvorakova M, Grof P
Arch Psychiatr Nervenkr (1970). 1982;232(2):157-66. doi: 10.1007/BF00343696.
The results are reported of a genealogic study of 313 patients (171 males and 142 females) consecutively admitted to the psychiatric department of the Medical School of Charles University in Prague, Czechoslovakia. Patients suffering from psychosis were selected and divided into five groups: "schizophrenia", "bipolar psychosis", "unipolar depressive psychosis", "schizoaffective psychosis" and "unspecified disorder" (the diagnosis of psychosis suspected but not yet certain at the time of investigation). A total of 1086 first degree relatives (parents and siblings) were ascertained and one or more first degree relatives of each proband were interviewed. The total morbidity risk of psychiatric disorder for parents and siblings was 12.6% for schizophrenic probands, 17.8% for bipolar probands, 10.7% for unipolar probands, 12.0% for schizoaffective probands and 12.6% for probands with unspecified psychosis. A striking increase of the frequency of affective disorders was found among secondary cases of schizoaffective probands. Heterogeneity between schizophrenia and primary affective disorders was tested and demonstrated. The pros and cons of the study design was discussed.
本文报告了对捷克斯洛伐克布拉格查理大学医学院精神科连续收治的313例患者（171例男性和142例女性）进行的系谱研究结果。选取患有精神病的患者并分为五组：“精神分裂症”、“双相情感障碍”、“单相抑郁性精神病”、“分裂情感性精神病”和“未特定的精神障碍”（调查时疑似但尚未确诊的精神病诊断）。共确定了1086名一级亲属（父母和兄弟姐妹），并对每个先证者的一名或多名一级亲属进行了访谈。精神分裂症先证者的父母和兄弟姐妹患精神障碍的总发病风险为12.6%，双相情感障碍先证者为17.8%，单相情感障碍先证者为10.7%，分裂情感性精神病先证者为12.0%，未特定精神病先证者为12.6%。在分裂情感性精神病先证者的二级病例中发现情感障碍的频率显著增加。对精神分裂症和原发性情感障碍之间的异质性进行了检验并得到证实。讨论了该研究设计的优缺点。
