Angst J, Felder W, Lohmeyer B
J Affect Disord. 1979 Jun;1(2):139-53. doi: 10.1016/0165-0327(79)90033-8.
1004 first degree relatives fo 150 schizoaffective patients (41 males, 109 females) were studied and a total morbidity risk of 29.6% of schizoaffective spectrum disorders were found. The relatives show an increased morbidity risk for schizophrenia (5.26%) and affective disorder (6.55%) with a high incidence of catatonia and unipolar depression; schizoaffective secondary cases were only found in 3%. There is no significant difference in morbidity between parents, siblings and children. The morbidity risk of neuroses is 5.3%, for personality disorders 7.2% and for suicides without spectrum diagnosis 1.8%. Off-spring of affected parents show a morbidity risk twice as high as that of off-spring of non-affected parents. The findings do not support the present concept of the ICD (International Classification of Disorders) of WHO, which subsumes schizoaffective disorders under the major rubric of schizophrenia. From a genetic viewpoint schizoaffective disorder takes an intermediate position between schizophrenia and affective disorders. None of the present hypotheses of the mode of inheritance is supported by the findings.
对150例分裂情感性障碍患者（41例男性，109例女性）的1004名一级亲属进行了研究，发现分裂情感性谱系障碍的总发病风险为29.6%。这些亲属患精神分裂症（5.26%）和情感障碍（6.55%）的发病风险增加，紧张症和单相抑郁的发病率较高；仅3%发现有分裂情感性障碍继发病例。父母、兄弟姐妹和子女之间的发病率无显著差异。神经症的发病风险为5.3%，人格障碍为7.2%，无谱系诊断的自杀为1.8%。患病父母的后代发病风险是非患病父母后代的两倍。这些发现不支持世界卫生组织国际疾病分类（ICD）目前的概念，即把分裂情感性障碍归入精神分裂症的主要类别之下。从遗传学观点来看，分裂情感性障碍处于精神分裂症和情感障碍之间的中间位置。目前关于遗传方式的假设均未得到这些发现的支持。
