Mendling W, Plempel M
Chemotherapy. 1982;28 Suppl 1:43-7. doi: 10.1159/000238151.
Patients with a mycologically confirmed vaginal mycosis were treated either with one 100-mg vaginal ovule of clotrimazole each for 6 days, or with one 200-mg vaginal ovule of clotrimazole each for 3 days, or with one 500-mg vaginal ovule of clotrimazole for 1 day, the ovule having been supplied in a novel, acid formulation. 24, 48 and 72 h after the last dose, samples of secretion were taken from the fornix vaginae. The intravaginal secretion levels were determined semiquantitatively on the basis of the measured inhibition zones obtained with Candida albicans growth on agar plates, and the levels obtained with the different treatment regimens were compared. The vaginal secretion levels after a single 500-mg dose of the new formulation were higher, even after 3 days, than those measured in the 6-day treatment, while administration of 200 mg clotrimazole on 3 days resulted in no increase of the secretion levels over those seen in 6-day treatment with 100 mg.
真菌学确诊的阴道霉菌病患者，分别接受以下治疗：每日使用1粒100毫克克霉唑阴道栓，共6天；或每日使用1粒200毫克克霉唑阴道栓，共3天；或使用1粒500毫克克霉唑阴道栓，仅用1天，该阴道栓采用新型酸性配方。在最后一剂用药后24、48和72小时，从阴道穹窿采集分泌物样本。根据在琼脂平板上白色念珠菌生长所获得的测量抑菌圈，对阴道内的分泌物水平进行半定量测定，并比较不同治疗方案所获得的水平。即使在3天后，单次使用500毫克新配方药物后的阴道分泌物水平，高于6天治疗方案所测得的水平，而连续3天使用200毫克克霉唑，与连续6天使用100毫克克霉唑相比，分泌物水平并无增加。
