Guillemin M P, Bauer D, Martin B, Marazzi A
Int Arch Occup Environ Health. 1982;51(2):139-50. doi: 10.1007/BF00378158.
An industrial hygiene study of 10 glassfiber reinforced polyester plants (including 90 workers) was undertaken to investigate the styrene exposure in this industry and to estimate biological limit values (BLV's) for the urinary metabolites of styrene: mandelic (MA) and phenylglyoxylic acids (PGA). Time weighted average (TWA) styrene exposures were found ranging from 2 to 200 ppm. The urinary elimination of metabolites correlated well with exposure and the BLV's corresponding to an 8-h exposure at 100 ppm were consistent with earlier laboratory findings (end-of-shift sample: MA 1640, PGA 510, MA + PGA 2150; next-morning sample: MA 330, PGA 330, MA + PGA 660 mg/g creat.). Total metabolites (MA + PGA) in the next-morning sample or mandelic acid in the end-of-shift sample are recommended for routine monitoring of exposure to styrene. The study revealed the need for further research on how to reduce styrene exposure in this industry.
开展了一项针对10家玻璃纤维增强聚酯工厂（包括90名工人）的工业卫生研究，以调查该行业中的苯乙烯暴露情况，并估算苯乙烯尿代谢物：扁桃酸（MA）和苯乙醛酸（PGA）的生物限值（BLV）。发现时间加权平均（TWA）苯乙烯暴露范围为2至200 ppm。代谢物的尿排泄与暴露密切相关，对应于100 ppm下8小时暴露的BLV与早期实验室结果一致（下班时样本：MA 1640、PGA 510、MA + PGA 2150；次日早晨样本：MA 330、PGA 330、MA + PGA 660 mg/g肌酐）。建议将次日早晨样本中的总代谢物（MA + PGA）或下班时样本中的扁桃酸用于苯乙烯暴露的常规监测。该研究表明有必要进一步研究如何降低该行业中的苯乙烯暴露。
