Tenniswood M P, Abrahams P P, Bird C E, Clark A F
Arch Androl. 1982 Dec;9(4):283-91. doi: 10.3109/01485018208990252.
Certain characteristics of acid phosphatase in the adult male rat are under androgenic control. In further investigations of this control, (1) the polyacrylamide gel electrophoretic pattern of enzyme activity, (2) enzyme specific activity, and (3) the extent of inhibition of enzyme activity by 1-tartrate were examined for prostate, seminal vesicles, kidney, liver and testes from immature, maturing, young, and old mature adult rats. On gel electrophoresis, lysosomal acid phosphatase activity was found for all tissues from all groups of animals. Secretory enzyme was found for the prostate gland, but only after maturation (it appeared between days 28 and 35). At the same time the percent inhibition of activity by tartrate decreases. For the other tissues, the percent inhibition by tartrate increases for the liver and seminal vesicles but not for the kidney and testes. These changes may reflect alterations in lysosomal enzyme characteristics and can be related to known changes in androgen production throughout the life span of the rat.
成年雄性大鼠酸性磷酸酶的某些特性受雄激素控制。在对这种控制的进一步研究中，检测了未成熟、成熟过程中、年轻和老龄成年大鼠的前列腺、精囊、肾脏、肝脏和睾丸的（1）酶活性的聚丙烯酰胺凝胶电泳图谱、（2）酶比活性以及（3）L-酒石酸盐对酶活性的抑制程度。在凝胶电泳中，所有动物组的所有组织均发现溶酶体酸性磷酸酶活性。前列腺中发现了分泌性酶，但仅在成熟后（出现在第28天至35天之间）。与此同时，酒石酸盐对活性的抑制百分比降低。对于其他组织，肝脏和精囊的酒石酸盐抑制百分比增加，但肾脏和睾丸则没有。这些变化可能反映了溶酶体酶特性的改变，并且可能与大鼠整个生命周期中雄激素产生的已知变化有关。
