血清甘氨胆酸测定在各种肝脏疾病中的临床应用价值。
Clinical usefulness of serum cholylglycine determination in various liver diseases.
作者信息
Tanggo Y, Fujiyama S, Kin F, Tashiro A, Shiraoku H, Akahoshi M, Sato Y, Hashiguchi O, Sagara K
出版信息
Gastroenterol Jpn. 1982 Oct;17(5):447-52. doi: 10.1007/BF02774722.
In order to study the clinical significance of cholylglycine (CG), CG in both fasting levels and after oral loading of 300 mg ursodeoxycholic acid (UDCA) were determined by radioimmunoassay in 313 patients with various liver diseases. Elevated fasting CG levels were found in 66.6% of patients with acute hepatitis (AH), 34.8% chronic inactive hepatitis (CIH), 79.3% chronic active hepatitis (CAH), 97.1% liver cirrhosis (LC), 94.7% hepatocellular carcinoma (HCC), and 80% of gall stones (GS). Changes of fasting CG during the course of AH were found to be parallel with values of transaminases. On oral loading of UDCA, different CG responses were found in CIH and CAH, and in compensated and decompensated LC. From these results we concluded that the determinations of serum CG gave additional informations of various liver diseases.
为研究甘氨胆酸（CG）的临床意义，采用放射免疫分析法测定了313例各种肝病患者空腹时及口服300mg熊去氧胆酸（UDCA）后的CG水平。结果发现，急性肝炎（AH）患者中66.6%空腹CG水平升高，慢性迁延性肝炎（CIH）患者中34.8%，慢性活动性肝炎（CAH）患者中79.3%，肝硬化（LC）患者中97.1%，肝细胞癌（HCC）患者中94.7%，胆结石（GS）患者中80%。AH病程中空腹CG的变化与转氨酶值平行。口服UDCA后，CIH和CAH以及代偿期和失代偿期LC患者的CG反应不同。从这些结果我们得出结论，血清CG的测定为各种肝病提供了更多信息。
Zotero 插件