Angelico M, Attili A F, Capocaccia L
Am J Dig Dis. 1977 Nov;22(11):941-6. doi: 10.1007/BF01076191.
Postprandial serum bile acid estimation was recently proposed as the most sensitive test of liver function. In our study, the fasting and postpranidal serum bile acid measurements were performed on 19 normal subjects, 20 patients with cirrhosis, 10 with acute hepatitis, 4 with resolving viral hepatitis, and 6 with chronic active hepatitis. A gas-chromatographic method was used. One healthy subject had postprandial serum bile acid levels above the normal range, while 7 patients with liver disease had postprandial levels within normal limits. Of the latter group, 2 had chronic active hepatitis in remission and 3 had resolving viral hepatitis. Significant correlations were seen between serum bile acid levels and most of the conventional "liver function" tests. Our data indicate that the postprandial serum bile acid determination is better than any of the other conventional tests taken separately, but no better than their combined use. No significant modification of the cholic acid/chenodeoxycholic acid ratio was observed between the fasting and the postprandial determinations.
餐后血清胆汁酸测定最近被提议作为肝功能最敏感的检测方法。在我们的研究中，对19名正常受试者、20名肝硬化患者、10名急性肝炎患者、4名正在康复的病毒性肝炎患者和6名慢性活动性肝炎患者进行了空腹和餐后血清胆汁酸测量。采用气相色谱法。1名健康受试者的餐后血清胆汁酸水平高于正常范围，而7名肝病患者的餐后水平在正常范围内。后一组中，2例慢性活动性肝炎处于缓解期，3例正在康复的病毒性肝炎。血清胆汁酸水平与大多数传统“肝功能”检测之间存在显著相关性。我们的数据表明，餐后血清胆汁酸测定比单独使用的任何其他传统检测方法都要好，但并不比它们联合使用更好。空腹和餐后测定之间未观察到胆酸/鹅去氧胆酸比值的显著变化。
