聚维酮碘化合物、吞噬细胞与微生物之间的相互作用。
Interaction of povidone-iodine compounds, phagocytic cells, and microorganisms.
作者信息
Van den Broek P J, Buys L F, Van Furth R
出版信息
Antimicrob Agents Chemother. 1982 Oct;22(4):593-7. doi: 10.1128/AAC.22.4.593.
Abstract
The interaction between povidone-iodine, phagocytic cells, and microorganisms was studied. Three preparations of povidone-iodine were investigated: commercially available povidone-iodine solution Betadine, pure high-molecular-weight povidone-iodine as used in Betadine, and a low-molecular-weight povidone-iodine. Low concentrations of povidone-iodine (approximately 0.005%) have considerable activity in vitro. The concentrations used clinically (0.1 to 20%) are toxic for granulocytes and monocytes. Leukocytes reduce the in vitro microbicidal activity of povidone-iodine. No differences of any importance were found between the three preparations of povidone-iodine.
摘要
研究了聚维酮碘、吞噬细胞和微生物之间的相互作用。研究了三种聚维酮碘制剂：市售聚维酮碘溶液碘伏、碘伏中使用的纯高分子量聚维酮碘和低分子量聚维酮碘。低浓度的聚维酮碘（约0.005%）在体外具有相当大的活性。临床使用的浓度（0.1%至20%）对粒细胞和单核细胞有毒性。白细胞会降低聚维酮碘的体外杀菌活性。三种聚维酮碘制剂之间未发现任何重要差异。
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