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人类补体成分C6和C7的特性分析

Characterization of human complement components C6 and C7.

作者信息

Discipio R G, Gagnon J

出版信息

Mol Immunol. 1982 Nov;19(11):1425-31. doi: 10.1016/0161-5890(82)90189-4.

DOI:10.1016/0161-5890(82)90189-4
PMID:7183910
Abstract

Human complement components C6 and C7 have been purified and characterized. Component C6 is a single-chain plasma protein of mol. wt 104,800 containing 3.8% carbohydrate and it has alanine as the amino terminal residue. Component C7 is a single-chain plasma protein of mol. wt 92,400 containing 6.4% carbohydrate and it has serine as the amino terminal residue. Primary sequence analysis failed to provide evidence of homology between these two proteins.

摘要

人补体成分C6和C7已被纯化并进行了特性鉴定。成分C6是一种单链血浆蛋白,分子量为104,800,含3.8%的碳水化合物,其氨基末端残基为丙氨酸。成分C7是一种单链血浆蛋白,分子量为92,400,含6.4%的碳水化合物,其氨基末端残基为丝氨酸。一级序列分析未能提供这两种蛋白质之间存在同源性的证据。

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1
Characterization of human complement components C6 and C7.人类补体成分C6和C7的特性分析
Mol Immunol. 1982 Nov;19(11):1425-31. doi: 10.1016/0161-5890(82)90189-4.
2
Functionally active complement proteins C6 and C7 detected in C6- and C7-deficient individuals.在C6和C7缺陷个体中检测到具有功能活性的补体蛋白C6和C7。
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[Clinical significance of C6, C7, C9 and C1-INH analysis].[C6、C7、C9及C1抑制物分析的临床意义]
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Structural similarities between C6 and C7 of human complement.
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A case of hereditary combined deficiency of complement components C6 and C7 in man.一例人类补体成分C6和C7遗传性联合缺陷病例。
Clin Exp Immunol. 1989 Mar;75(3):396-401.
7
Structural homology of complement protein C6 with other channel-forming proteins of complement.补体蛋白C6与补体其他形成通道蛋白的结构同源性。
Proc Natl Acad Sci U S A. 1989 Apr;86(8):2799-803. doi: 10.1073/pnas.86.8.2799.
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