Watanabe A, Miyazaki M
Acta Hepatogastroenterol (Stuttg). 1977 Aug;24(4):238-40.
The rate of alpha-fetoprotein (AFP) catabolism in carbon tetrachloride (CCl4)-treated rats was estimated to be essentially the same as that found in control adult and young rats. The blockade of the reticuloendothelial system by carbon particle resulted in slightly shorter t1/2 values of AFP. The amount of AFP synthesized pet day in CCl4-treated rats was theoretically calculated to be nearly 10-fold increase over that in control rats. Thus, the elevation of serum AFP concentrations in CCl4-treated rats is derived from the increased synthesis of AFP by injured liver.
据估计，四氯化碳（CCl4）处理的大鼠中甲胎蛋白（AFP）的分解代谢速率与对照成年大鼠和幼年大鼠中的分解代谢速率基本相同。碳颗粒对网状内皮系统的阻断导致AFP的半衰期值略短。理论计算得出，CCl4处理的大鼠中每天合成的AFP量比对照大鼠增加近10倍。因此，CCl4处理的大鼠血清AFP浓度升高源于受损肝脏中AFP合成增加。
