米索硝唑与顺铂复合物的联合研究：体外细胞毒性和放射增敏作用
Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro.
作者信息
Stratford I J, Williamson C, Adams G E
出版信息
Br J Cancer. 1980 Apr;41(4):517-22. doi: 10.1038/bjc.1980.93.
Abstract
cis-Dichlorodiammineplatinum(II) (cis-Pt(II) can act as a radiosensitizer of hypoxic mammalian cells in vitro. Used in combination with misonidazole the level of sensitization achieved is greater than that seen with either drug alone, and it is suggested that these compounds sensitize by independent mechanisms. For cells held at 37 degrees C, cis-Pt(II) shows much greater toxicity to hypoxic cells than to aerobic cells. In combination with misonidazole, no additional cytotoxic effect is shown towards aerobic cells than that seen for cis-Pt(II) alone. However, there is additional killing of hypoxic cells when they are treated with both drugs.
摘要
顺式二氯二氨合铂（II）（顺铂（II））在体外可作为缺氧哺乳动物细胞的放射增敏剂。与米索硝唑联合使用时，所达到的增敏水平高于单独使用任何一种药物时的水平，并且有人认为这些化合物通过独立的机制发挥增敏作用。对于在37℃下培养的细胞，顺铂（II）对缺氧细胞的毒性比对有氧细胞的毒性大得多。与米索硝唑联合使用时，对有氧细胞没有显示出比单独使用顺铂（II）时更大的细胞毒性作用。然而，当用两种药物处理缺氧细胞时，会有额外的杀伤作用。
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