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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Davison J S, Schofield B

Pflugers Arch. 1980 Jul;386(1):53-7. doi: 10.1007/BF00584187.

Distention of the vagally denervated fundic gland area, although by itself a generally ineffective stimulus to acid secretion in this study, will markedly increase the acid secretory response to stimulation by endogenous gastrin, pentagastrin and histamine. Even maximal responses to histamine can be increased, thus demonstrating true potentiation between distention and humoral stimuli. 2. The magnitude of the distention potentiation does not appear to be influenced by the nature of the background stimulus or the background level of secretion. 3. The distention potentiation of the response to histamine is reduced but not abolished by intravenous atropine and hexamethonium. Thus, there appear to be two components to the local distention mechanism. One is cholinergic, the other, atropine-resistant component is possibly non-cholinergic. At least one of these components, possibly the cholinergic, involves a nicotinic synapse in its pathway.

迷走神经切断的胃底腺区扩张，尽管在本研究中其本身对胃酸分泌通常是无效刺激，但会显著增强对内源性胃泌素、五肽胃泌素和组胺刺激的胃酸分泌反应。甚至对组胺的最大反应也能增强，从而证明扩张与体液刺激之间存在真正的增强作用。2. 扩张增强的程度似乎不受背景刺激的性质或分泌的背景水平影响。3. 静脉注射阿托品和六甲铵可使对组胺反应的扩张增强作用减弱但未消除。因此，局部扩张机制似乎有两个组成部分。一个是胆碱能的，另一个对阿托品有抗性的成分可能是非胆碱能的。这些成分中至少有一个，可能是胆碱能成分，在其途径中涉及一个烟碱样突触。

Davison J S, Schofield B

Pflugers Arch. 1980 Jul;386(1):53-7. doi: 10.1007/BF00584187.

Distention of the vagally denervated fundic gland area, although by itself a generally ineffective stimulus to acid secretion in this study, will markedly increase the acid secretory response to stimulation by endogenous gastrin, pentagastrin and histamine. Even maximal responses to histamine can be increased, thus demonstrating true potentiation between distention and humoral stimuli. 2. The magnitude of the distention potentiation does not appear to be influenced by the nature of the background stimulus or the background level of secretion. 3. The distention potentiation of the response to histamine is reduced but not abolished by intravenous atropine and hexamethonium. Thus, there appear to be two components to the local distention mechanism. One is cholinergic, the other, atropine-resistant component is possibly non-cholinergic. At least one of these components, possibly the cholinergic, involves a nicotinic synapse in its pathway.

迷走神经切断的胃底腺区扩张，尽管在本研究中其本身对胃酸分泌通常是无效刺激，但会显著增强对内源性胃泌素、五肽胃泌素和组胺刺激的胃酸分泌反应。甚至对组胺的最大反应也能增强，从而证明扩张与体液刺激之间存在真正的增强作用。2. 扩张增强的程度似乎不受背景刺激的性质或分泌的背景水平影响。3. 静脉注射阿托品和六甲铵可使对组胺反应的扩张增强作用减弱但未消除。因此，局部扩张机制似乎有两个组成部分。一个是胆碱能的，另一个对阿托品有抗性的成分可能是非胆碱能的。这些成分中至少有一个，可能是胆碱能成分，在其途径中涉及一个烟碱样突触。