Randall C L, Lochry E A, Moseley J W, Sutker P B
Pharmacol Biochem Behav. 1981 Aug;15(2):191-5. doi: 10.1016/0091-3057(81)90176-3.
This study tested the hypothesis that decreased estrogen levels accomplished by removing the ovaries affect the response to acutely administered alcohol in female mice. Sensitivity to alcohol was measured in ovariectomized, sham-operated, and non-surgical control C3H/HEN mice. Each animal received an IP injection of alcohol (3.0 or 4.0 g/kg). Core temperature, fall time, sleep time, and waking blood alcohol levels were the dependent variables. For each of these measures, alcohol sensitivity was found to be a function of the dose of alcohol administered, but not the surgical condition. Additionally, the stage of estrus in control animals was not found to be related to alcohol sensitivity.
通过切除卵巢降低雌激素水平会影响雌性小鼠对急性给予酒精的反应。在卵巢切除、假手术和未做手术的对照C3H/HEN小鼠中测量对酒精的敏感性。每只动物腹腔注射酒精（3.0或4.0克/千克）。核心体温、下降时间、睡眠时间和清醒时的血液酒精水平为因变量。对于这些测量指标中的每一项，发现酒精敏感性是所给予酒精剂量的函数，而非手术情况的函数。此外，未发现对照动物的发情阶段与酒精敏感性有关。
