Shipochliev T, Dimitrov A, Aleksandrova E
Vet Med Nauki. 1981;18(6):87-94.
Use was made of Wistar albino rats in which an inflammation was induced via the simultaneous injection of caraginan and prostaglandin E1 in order to evaluate the antiinflammatory activity of 6 freeze dried plant extracts. It was found that with such model of inflammation the inflammatory effect of caraginan was strongly enhanced, which was accompanied by the rapid and prolific white blood cell extravasates. The freeze-dried extracts of St. John's-wort (Hypericum perforatum L.), potmarigold calendula (Calendula officinalis L.), camomile (Matricaria chamomilla L.) and plantain (Plantago lanceolata L. et Pl. major L.) were found to suppress both the inflammatory effect and the leukocyte infiltration. The extracts of symphytum (Symphytum officinale L.) and those of flax seed (Linum usitatissimum L.) did not inhibit the inflammation, however, they suppressed the leukocyte infiltration at the 3rd and 4th hour of the induced inflammation.
为了评估6种冻干植物提取物的抗炎活性,使用了Wistar白化大鼠,通过同时注射角叉菜胶和前列腺素E1诱导炎症。发现在这种炎症模型中,角叉菜胶的炎症作用显著增强,同时伴有快速且大量的白细胞渗出。结果发现,金丝桃(Hypericum perforatum L.)、金盏花(Calendula officinalis L.)、洋甘菊(Matricaria chamomilla L.)和车前草(Plantago lanceolata L. et Pl. major L.)的冻干提取物既能抑制炎症作用,又能抑制白细胞浸润。聚合草(Symphytum officinale L.)和亚麻籽(Linum usitatissimum L.)的提取物虽未抑制炎症,但在诱导炎症的第3小时和第4小时抑制了白细胞浸润。