Lee T D, Wakelin D
Int Arch Allergy Appl Immunol. 1982;67(4):302-5. doi: 10.1159/000233037.
A proportion of DBA/2 mice do not reject the large intestinal nematode parasite Trichuris muris. In this strain and the early rejecting NIH and the late rejecting CBA/Ca strains the kinetics of the mast cell accumulation in a primary infection were similar with peak mast cell numbers being recorded on day 20 post-infection. Comparisons between rejector and non-rejector DBA/2 mice showed no differences in the mast cell accumulation. There was no rise in mast cell numbers in response to a secondary infection, in either the NIH or CBA/Ca strains, for at least 3 days after the infection had been expelled. It is suggested that mucosal mast cell accumulation is not induced by a simple response to parasite factors, that the cells are not directly involved in the expulsion of T. muris and that any role they play in the spontaneous cure response is subject to more complex control.
一部分DBA/2小鼠不会排斥大肠线虫寄生虫毛首鞭形线虫。在这个品系以及早期排斥的NIH品系和晚期排斥的CBA/Ca品系中，初次感染时肥大细胞积累的动力学相似，在感染后第20天记录到肥大细胞数量达到峰值。对排斥和不排斥的DBA/2小鼠进行比较，结果显示肥大细胞积累没有差异。在NIH或CBA/Ca品系中，寄生虫被排出后至少3天内，再次感染均未引起肥大细胞数量增加。这表明黏膜肥大细胞的积累不是由对寄生虫因子的简单反应诱导的，这些细胞不直接参与毛首鞭形线虫的排出，并且它们在自发治愈反应中所起的任何作用都受到更复杂的调控。
